| 李卫勤,韩 康,邢永军,杨智泉,党培业,李耀章,祁 健,王彦东.丁丙诺啡透皮贴剂对慢性膝骨性关节炎疼痛的控制效果评价[J].,2017,17(33):6483-6486 |
| 丁丙诺啡透皮贴剂对慢性膝骨性关节炎疼痛的控制效果评价 |
| Evaluation of the Efficacy and Safety of Buprenorphine Transdermal Patches in Patients with Knee Osteoarthritis |
| 投稿时间：2017-05-08 修订日期：2017-05-31 |
| DOI：10.13241/j.cnki.pmb.2017.33.018 |
| 中文关键词: 膝关节骨性关节炎 丁丙诺啡透皮贴 视觉模拟量表评分 |
| 英文关键词: Knee osteoarthritis Buprenorphine transdermal patches Visual analog scale score |
| 基金项目:国家自然科学基金项目(31500856) |
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| 中文摘要: |
| 摘要 目的：探讨和比较丁丙诺啡透皮贴剂对于膝骨性关节炎所导致的慢性疼痛的治疗效果和安全性评价。方法：将2014.01年至2016.01年符合纳入及排除标准的共计112例患者随机分为两组。按照使用药物的不同将其分为实验组和对照组，各28例。实验组使用丁丙诺啡透皮贴（5 mg），贴于上臂。对照组使用塞来昔布，20 mg，口服，2次/日。用药后每周对其观察1次，4周为一观察疗程。使用VAS疼痛评分标准，骨关节炎指数（WOMAC），并发症等指标对患者在治疗前后的疼痛情况进行判断和比较。结果：两组患者在用药前的VAS评分及WOMAC评分相比无统计学差异(P>0.05)。用药后2周及4周两组患者较术前均有显著性改善，但两组间无统计学差异。两组患者在并发症等方面未见显著性差异(P>0.05)。结论：丁丙诺啡透皮贴剂相对于塞来昔布在膝关节骨性关节炎的疼痛方面具有几乎相同的良好控制效果，在并发症方便也并无差异，但使用更加方便，在今后的临床工作中可以选择合适的病人进一步推广使用。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the clinical efficacy and safety of using buprenorphine transdermal patch in the treatment of pa- tients with knee osteoarthritis. Methods: 112 cases of knee osteoarthritis were divided into 2 groups: the experimental group (n=56) was treated with a total of two patches of buprenorphine (5 mg) transdermal patch on the outside of upper arm, and each patch had been kept for 7 days. The control group (n=56) was given 20 mg celecoxib orally twice daily for two weeks. patients were standardized using anal- gesics according to the VAS score. McMaster Universities Osteoarthritis Index (WOMAC), and adverse reactions. Results: 112 cases of knee osteoarthritis patients were observed. The visual analog scale (VAS) reported by patients in the experimental group and the control group were significantly decreased after two weeks treatment(P<0.05). However, there was no significant difference between 2 groups. The WOMAC score in the experiment group and the control group were significantly decreased after the treatment (P<0.05). There was no significant difference between the two groups (P>0.05). There was no significant difference between 2 groups in complication and ad- verse reactions. Conclusion: Buprenorphine transdermal patches is at least as effective as celecoxib in treating knee osteoarthritis which could be further used in clinic therapy because of its easy using. |
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