| 房国祥,余厚友,支少敏,席 敏,王 莹.布洛芬辅助治疗下调氟西汀疗效不佳小鼠海马炎症因子表达改善抑郁样行为[J].,2017,17(33):6437-6441 |
| 布洛芬辅助治疗下调氟西汀疗效不佳小鼠海马炎症因子表达改善抑郁样行为 |
| Ibuprofen Decreases Hippocampal Cytokines and Ameliorates Depressive-like Behaviors in Fluoxetine Treatment Resistant Mice |
| 投稿时间：2017-07-24 修订日期：2017-08-19 |
| DOI：10.13241/j.cnki.pmb.2017.33.008 |
| 中文关键词: 难治性抑郁 布洛芬 IL-1β PGE2 行为学 |
| 英文关键词: Treatment resistant depression Ibuprofen IL-1β PGE2 Behavioral tests |
| 基金项目:国家自然科学基金项目（81671343） |
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| 中文摘要: |
| 摘要 目的：探讨布洛芬辅助治疗对氟西汀疗效不佳抑郁小鼠海马炎症因子表达及抑郁样行为的影响。方法：采用慢性不可预见性温和刺激制备抑郁模型，通过糖水偏爱试验、强迫游泳试验以及新奇环境抑制摄食试验等筛查氟西汀疗效不佳抑郁小鼠，将该小鼠随机分为2组，一组继续氟西汀治疗，另一组给予布洛芬辅助治疗，2周后评价2组小鼠抑郁样行为的变化及海马白细胞介素1β（Interleukin 1β，IL-1β）、前列腺素E2（Prostaglandin E2，PGE2）的表达情况。结果：大约20-30%的抑郁小鼠氟西汀治疗效果不佳，其海马IL-1β、PGE2水平明显高于对照组以及氟西汀治疗有效小鼠(P<0.05)。布洛芬辅助治疗下调氟西汀疗效不佳抑郁小鼠海马IL-1β、PGE2水平，小鼠的糖水消耗及糖耗比值均较单纯氟西汀治疗组明显提高(P<0.05)；小鼠强迫游泳的不动时间明显缩短(P<0.05)。并且在新奇环境中的摄食行为增强，摄食潜伏期缩短(P<0.05)。结论：布洛芬对氟西汀治疗效果不佳(难治性)抑郁小鼠具有辅助抗抑郁治疗作用，能够下调炎症因子表达，改善其抑郁样行为。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of ibuprofen on the hippocampal cytokines and the depressive-like behaviors in the fluoxetine treatment resistant depressive mice. Methods: In this study, mice were subjected to chronic unpredictable mild stress (CUMS) and administered with fluoxetine treatment. The CUMS regimen and fluoxetine treatment were assessed by behavioral tests in- cluding sucrose preference test, forced swimming test and novelty suppressed feeding test to get fluoxetine treatment resistant depressive mice. And then, those mice were divided into two groups randomly and one group was administered augmentation treatment with ibupro- fen. We further investigated whether ibuprofen has the effects on the hippocampal IL-1β, PGE2 and the depressive-like behaviors in the fluoxetine treatment resistant mice. Results: 20-30% depressive mice were resistant to fluoxetine treatment, namely fluoxetine treatment resistant depressive mice. The levels of IL-1β and PGE2 in the hippocampus were higher than those of control and fluoxetine treatment responsive mice. Ibuprofen augmentation treatment significantly decreased the hippocampal IL-1β and PGE2. In fluoxetine treatment re- sistant depressive mice, Ibuprofen augmentation increased the sucrose consumption and preference (P<0.05), decreased the immobility time in forced swimming test(P<0.05) and shorten the latency to feeding in novelty suppressed feeding test (P<0.05). Conclusion: Ibuprofen augmentation treatment decreased hippocampal IL-1β and PGE2 and ameliorated depressive-like behaviors in fluoxetine treat- ment resistant mice. |
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