| 吴宗林,金 姝,童 平,耿 和,朱洪炜,唐 炯,张 涛,刘 翔,夏术阶.良性前列腺增生患者外周血Th17和Treg细胞比率的变化[J].,2017,17(32):6312-6314 |
| 良性前列腺增生患者外周血Th17和Treg细胞比率的变化 |
| Changes of Th17 and Treg Cell Ratio in the Peripheral Blood of Patients with Benign Prostatic Hyperplasia |
| 投稿时间：2017-03-08 修订日期：2017-03-31 |
| DOI：10.13241/j.cnki.pmb.2017.32.024 |
| 中文关键词: 前列腺增生 Th17细胞 Treg细胞 炎症 |
| 英文关键词: Benign prostatic hyperplasia Th17 cell Treg cells Inflammation |
| 基金项目:上海市卫生与计划生育委员会课题基金项目(20134419)；普陀区卫生系统学科带头人培养计划基金(普卫〔2012〕2号) |
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| 中文摘要: |
| 摘要 目的：探讨良性前列腺增生患者外周血Th17和Treg细胞比率的变化。方法：选择33例良性前列腺增生患者及19例正常对照者为研究对象，采用流式细胞术检测和比较其外周血中T淋巴细胞亚群及Th17和Treg细胞占CD4+T细胞的比率。结果：良性前列腺增生患者外周血Th17和Treg细胞占CD4+T细胞的比率分别为1.58±0.71和1.76±0.83，Th17/Treg的比率为0.89±0.42。正常健康对照者外周血Th17和Treg细胞占CD4+T细胞的比率分别为0.75±0.46和1.83±0.75，Th17/Treg的比率为0.41±0.32。良性前列腺增生患者外周血Th17占CD4+T细胞的比率和Th17/Treg的比率明显高于正常健康对照者(P<0.05)。结论：良性前列腺增生患者体内Th17细胞比率升高，Th17/Treg比率失衡，可能与良性前列腺增生的发生、发展有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the ratio of Th17 cells and CD4+CD25-Foxp3+ regulatory T (Treg) cells in the peripheral blood of patients with benign prostatic hyperplasia (BPH). Methods: The peripheral whole blood was obtained from patients with BPH(n=33) and healthy controls (n=19). The percentage of Th17 and Treg cells were analyzed by flow cytometry. Results: The percentage of Th17 and Treg cells to CD4+T lymphocyte in patient with BPH was 1.58±0.71 and 1.76±0.83, respectively. The ratio of Th17 to Treg cells in patients with BPH was 0.89±0.42. The percentage of Th17 and Treg cells to CD4+T lymphocyte in the healthy controls were 0.75±0.46 and 1.83±0.75, respectively. The ratio of Th17 to Treg cells in the healthy controls was 0.41±0.32. The percentage of Th17 cells and ratio of Th17 to Treg cells were significantly increased in patients with BPH compared with healthy controls. Conclusion: The increased percentage of Th17 cells made the imbalance of Th17 to Treg cells in patients with BPH. The imbalance might be involved in the pathogenesis of BPH. |
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