| 李徳璇,李亚山,汪 坚,张贝基,洪 颖,张琼月,钟 勇.非小细胞肺癌Survivin，Skp2和XIAP mRNA的表达及其临床意义[J].,2017,17(31):6159-6162 |
| 非小细胞肺癌Survivin，Skp2和XIAP mRNA的表达及其临床意义 |
| Expression and Clinical Significance of Survivin, Skp2 and XIAP mRNA in Non-Small Cell Lung Cancer |
| 投稿时间：2017-06-02 修订日期：2017-06-29 |
| DOI：10.13241/j.cnki.pmb.2017.31.037 |
| 中文关键词: 非小细胞肺癌 生存素 细胞S期激酶相关蛋白2 X 连锁凋亡抑制蛋白 临床意义 |
| 英文关键词: Non-small cell lung cancer Survivin Skp2 XIAP Clinical significance |
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| 中文摘要: |
| 摘要 目的：探讨非小细胞肺癌（NSCLC）生存素（Survivin）、S期激酶相关蛋白2（Skp2）和X连锁凋亡抑制蛋白（XIAP）mRNA的表达及其临床意义。方法：收集2014年4月到2017年5月期间我院182例NSCLC患者在手术中切除的病理组织作为研究组，另收集每例患者癌变组织旁5cm以外的癌旁组织作为对照组。比较两组的Survivin、Skp2和XIAP mRNA阳性率，并分析Sur- vivin、Skp2和XIAP mRNA表达与临床病理特征的关系。结果：研究组的Survivin、Skp2和XIAP mRNA阳性率显著高于对照组，差异有统计学意义（P<0.05）。Survivin mRNA的阳性表达与年龄、性别、组织类型、分化程度、临床分期、淋巴结转移、吸烟史无关（P>0.05）。Skp2 mRNA的阳性表达与年龄、性别、组织类型、分化程度、淋巴结转移、吸烟史无关（P>0.05），与临床分期相关（P<0.05）。XIAP mRNA的阳性表达与年龄、性别、组织类型、分化程度、吸烟史无关（P>0.05），与临床分期、淋巴结转移相关（P<0.05）。结论：Survivin、Skp2和XIAP mRNA在NSCLC患者的病理组织中呈高表达，Skp2 mRNA的阳性表达与临床分期有关，XIAP mRNA的阳性表达与临床分期、淋巴结转移有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of survivin(Survivin), S-phase kinase associated pro- tein 2(Skp2)and X-linked inhibitor of apoptosis protein (XIAP) mRNA in non-small cell lung cancer（NSCLC）. Methods: The patho- logical tissues of 182 patients with NSCLC, who underwent surgical resection in Third People's Hospital of Yunnan Province during April 2014 to May 2017, were collected as study group; in addition, the paracancerous tissues outside 5cm beside the cancerous tissue of each patient were collected as control group. The positive rates of Survivin, Skp2 and XIAP mRNA in the two groups were compared, and the relationship between the expressions of Survivin, Skp2 and XIAP and clinicopathological features of mRNA was analyzed. Results: The positive rates of Survivin, Skp2 and XIAP mRNA in the study group were significantly higher than those in the control group, and the difference was statistically significant(P<0.05). The positive expression of Survivin mRNA was not related to age, sex, tissue type, differentiation degree, clinical stage, lymph node metastasis and smoking history(P>0.05). The positive expression of Skp2 mRNA was not related to age, sex, tissue type, differentiation degree, lymph node metastasis and smoking history(P>0.05), but related to clinical stage(P<0.05). The positive expression of XIAP mRNA was not related to age, sex, tissue type, differentiation degree, smoking history(P>0.05), but related to clinical stage and lymph node metastasis(P<0.05). Conclusion: Survivin, Skp2 and XIAP mRNA are highly ex- pressed in the pathological tissues of patients with NSCLC. The positive expression of Skp2 mRNA is related to the clinical stage, and the positive expression of XIAP mRNA is related to the clinical stage and lymph node metastasis. |
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