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作者	单位	E-mail
丁荷蓓	江苏省南通大学附属海安医院麻醉科江苏海安 226600	dinghebei_2325@medicinepaper.cn
张稳稳	徐州医科大学附属医院麻醉科江苏徐州 221000
陈为国	江苏省南通大学附属海安医院麻醉科江苏海安 226600
王珣	江苏省南通大学附属海安医院麻醉科江苏海安 226600
曹苏	江苏省南通大学附属海安医院麻醉科江苏海安 226600

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中文摘要:

摘要目的：评价右美托咪定对硬腰联合麻醉下子宫肌瘤切除手术患者术中的镇静效果的影响。方法：选择2013年1月至2016年8月在我院行子宫肌瘤切除术的患者60例，随机分为两组，每组30例。对照组患者静脉注入丙泊酚60 μg/kg?h，观察组患者静脉注入右美托咪定0.4 μg/kg?h。分别记录患者术前、术中30 min以及术后的Ramsay评分、BIS评分、MAP、HR以及SpO₂等生命指征和术后不良反应发生的情况。结果：实验组患者术中30 min的镇静效果优于对照组，其中Ramsay评分显著高于对照组（P<0.05），且BIS评分显著低于对照组（P<0.05）。实验组患者术中30 min HR显著低于对照组（P<0.05），但是两组之间MAP以及SpO₂却没有明显差异（P>0.05）。比较两组患者术后不良反应发生的情况发现两者差异没有明显的统计学意义（P>0.05）。结论：右美托咪定在硬腰联合麻醉下子宫肌瘤切除术患者术中可以显著改善镇静作用，值得临床上进一步推广应用。

英文摘要:

ABSTRACT Objective: To evaluate the sedative potency of dexmedetomidine on patients undergoing hyteromyomectomy with spinal epidural analgesia. Methods: 60 patients undergoing hyteromyomectomy were enrolled from January 2013 to August 2016 in our hospital, which randomly divided into two groups, control group (n=30) were all injected 60 μg/kg?h propofol intravenously, and study group (n=30) were adopted 4 μg/kg?h dexmedetomidine. Ramsay and BIS score, MAP, HR and SpO₂ with pre-operation, post-operation and 30 min intra-operation was detected and compared between two groups. Results: The sedative potency with 30 min intra-operation of study group was better than that of control group, not only the Ramsay score was higher than the latter, but also the BIS score was lower than control group, which difference from two groups was significance (P<0.05). In the 30 min operation, HR of study group was obviously lower than control group (P<0.05), but the difference of MAP and SpO₂ between two groups was no significance (P>0.05). Comparing the incidence of adverse reaction of the control and study group, there was no significance (P>0.05). Conclusion: Dexmedetomidine has remarkable sedative potency in hysteromyomectomy with the spinal epidural analgesia, worthy of further popularization.

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