| 李跃英,齐 骥,姚 国,雷秀秀,张 萌.血清胱抑制素和血清转化因子-β1水平在新生儿窒息中的变化及意义[J].,2017,17(27):5354-5357 |
| 血清胱抑制素和血清转化因子-β1水平在新生儿窒息中的变化及意义 |
| Changes and Significances of Serum Cystatin C and Transforming Growth Factor-β1 Levels in the Neonatal Asphyxia |
| 投稿时间：2017-02-08 修订日期：2017-03-05 |
| DOI：10.13241/j.cnki.pmb.2017.27.039 |
| 中文关键词: 新生儿窒息 血清胱抑制素C 血清转化因子-β1 |
| 英文关键词: Neonatal asphyxia Serum cystatin C Transforming growth factor-β1 |
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| 中文摘要: |
| 摘要 目的：探究血清胱抑制素C和血清转化因子-β1在新生儿窒息中的变化及其临床意义。方法：选取2012年1月至2016年9月我院收治的窒息新生儿46例作为窒息组，将同期出生的足月健康新生儿30例作为对照组。分别检测两组新生儿入院后第1、3、7天的血清转化因子-β1(TGF-β1)、血清胱抑制素C(CysC)、血清尿素氮(BUN)、血清肌酐(Scr)及肾小球滤过率(GFR)水平的变化，并依据是否有肾功能损伤将窒息组46例新生儿分为正常组和损伤组，分析两组新生儿血清指标的变化差异。结果：入院后第1、3、7天，窒息组新生儿的TGF-β1、GFR呈现逐渐升高趋势，且均显著低于对照组(P<0.05)；而CysC、BUN及Scr呈现降低趋势，且均显著高于对照组(P<0.05)。肾功能损伤组的CysC、BUN及Scr显著高于正常组，TGF-β1、GFR显著低于正常组(P<0.05)。此外，损伤组的TGF-β1水平分别与血清BUN、Scr水平呈负相关关系，与GFR呈正相关关系；而血清CysC水平分别于血清BUN、Scr呈正相关关系，与GFR呈负相关关系(P均<0.05)。结论：窒息新生儿的血清TGF-β1、CysC水平均较健康新生儿有显著性变化，并与患儿肾功能显著相关，对患儿肾功能损伤的早期诊断、病情及预后判断有一定的临床指导意义。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the changes and significances of serum cystatin C and transforming growth factor-β1 levels for the neonatal asphyxia. Methods: Forty-six asphyxia newborns were chosen as the asphyxia group, and thirty healthy newborns were selected as the control group. The TGF-β1, CysC, BUN, Scr, and GFR levels of both groups were detected on the 1st, 3rd, 7th day after hospitalization. According to the renal injury, the 46 newborns were divided into normal group and asphyxia group, and the serum indexes were detected and analyzed. Results: On the 1st, 3rd, 7th day after hospitalization, the TGF-β1, GFR of asphyxia group was obviously in- creased and was lower than those of the control group (P<0.05); the level of CysC, BUN, Scr in both groups were decreased, and the change degree in asphyxia group were higher than that of the control group(P<0.05); the CysC, BUN, Scr in renal injured group were higher than those of normal group, and TGF-β1, GFR were much lower (P<0.05). Additionally, TGF-β1 level of renal injured group was negatively correlated to the BUN and Scr, and positively correlated with the GFR (P<0.05). The level of serum CysC in renal injured group was positively correlated to BUN and Scr and negatively correlated to GFR (P<0.05). Conclusion: The serum TGF-β1, CysC in as- phyxia newborns had significant changes compared with the healthy newborns and was correlated to the renal injured indexes, which had clinical directive significance on the early diagnosis, condition judgment, and prognosis of neonatal asphyxia with renal injury. |
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