| 顾恒琼,苏 鑫,吴玄豪,符永丰,许 阳.血浆纤维蛋白原和D-二聚体在老年NSCLC患者预后中的意义[J].,2017,17(27):5262-5266 |
| 血浆纤维蛋白原和D-二聚体在老年NSCLC患者预后中的意义 |
| Prognostic Significance of Plasma Fibrinogen and D-dimer in Elderly Patients with NSCLC |
| 投稿时间：2017-05-02 修订日期：2017-05-27 |
| DOI：10.13241/j.cnki.pmb.2017.27.015 |
| 中文关键词: 血浆纤维蛋白原 D-二聚体 非小细胞肺癌 预后 |
| 英文关键词: Fibrinogen D-dimer Non-small cell lung cancer Prognosis |
| 基金项目:国家自然科学基金面上项目（30370616）；解放军总医院苗圃科研基金项目（14KMM03） |
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| 中文摘要: |
| 摘要 目的：探讨老年非小细胞肺癌（non-small cell lung cancer, NSCLC）患者抗癌治疗前血浆纤维蛋白原（fibrinogen，FIB）和D-二聚体（D-dimer）的预后意义。方法：测定97例肺癌患者(肺癌组)及36 例健康体检者(对照组)血浆D-dimer、FIB水平并进行比较，并分析其与NSCLC临床病理因素之间关系及预后价值。结果：肺癌组血浆FIB、D-dimer水平高于健康对照组(P＜0.05)。肺癌组FIB与TNM分期有关，D-dimer与淋巴结转移和TNM分期有关。单因素分析提示FIB、D-dimer、肿瘤大小、淋巴结转移、TNM分期与总体生存时间（overall survival，OS）和无进展生存时间（progression free survival，PFS）相关，而多因素分析仅提示D-dimer、FIB是老年NSCLC患者的独立危险预后因素。结论：检测老年NSCLC患者抗癌治疗前纤维蛋白原和D-二聚体可以指导预后，为肺癌个体化治疗提供一定的参考价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the prognostic significance of plasma fibrinogen (FIB) and D-dimer in elderly patients with non-small cell lung cancer (NSCLC) before any anti-cancer treatments. Methods: 97 cases of patients with lung cancer (lung cancer group) and 36 healthy subjects (control group) were enrolled; the level of plasma D-dimer and FIB were compared; the relationship be- tween their levels and clinical pathological factors of NSCLC as well as prognosis was analyzed. Results: The levels of plasma FIB and D-dimer in lung cancer group were higher than those in healthy control group (P<0.05). FIB in lung cancer group was related to TNM stage, and D-dimer was related to lymph node metastasis and TNM stage. Univariate analysis showed that FIB, D-dimer, tumor size, lymph node metastasis and TNM staging were associated with overall survival time (OS) and progression free survival (PFS). Multivari- ate analysis revealed that only D-dimer and FIB were independent prognostic factors of patients with NSCLC. Conclusion: Detection of fibrinogen and D-dimer in elderly patients with NSCLC before anti-cancer treatment would be useful for prognosis and might provide a certain value for individualized therapy. |
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