| 姚 矾,路 亮,张立翱,郑可佳,金 水.血清GP73联合Dickkopf-1、AFP对肝细胞癌的诊断价值[J].,2017,17(26):5153-5156 |
| 血清GP73联合Dickkopf-1、AFP对肝细胞癌的诊断价值 |
| Diagnostic Value of Serum GP73 Combined with Dickkopf-1 and AFP in Hepatocellular Carcinoma |
| 投稿时间：2016-12-03 修订日期：2016-12-30 |
| DOI：10.13241/j.cnki.pmb.2017.26.035 |
| 中文关键词: GP73 Dickkopf-1 肝细胞癌 诊断价值 |
| 英文关键词: Golgi protein 73 Dickkopf-1 Hepatocellular carcinoma Diagnostic value |
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| 中文摘要: |
| 摘要 目的：探讨血清高尔基体蛋白（GP73）联合Dickkopf-1、甲胎蛋白（AFP）对肝细胞癌的诊断价值。方法：收集2014年9月至2016年9月我院收治的117例肝细胞癌患者（肝细胞癌组）、80例乙型病毒性肝炎患者（肝炎组），以及随机选取的80例健康体检者（对照组）为研究对象，采用酶联免疫吸附法（ELISA）测定各组对象的血清GP73、Dickkopf-1、AFP水平，并分析其与临床病理特征之间的关系，分析GP73、Dickkopf-1、AFP联合对肝细胞癌的诊断价值。结果：肝细胞癌组血清GP73、Dickkopf-1、AFP水平高于肝炎组、对照组，且肝炎组血清AFP水平高于对照组，差异有统计学意义（P<0.05）。Child Pugh分级中B~C级肝细胞癌患者GP73、Dickkopf-1、AFP水平高于A级，差异有统计学意义（P<0.05），不同分化程度、肿瘤直径、肿瘤数目患者的GP73、Dickkopf-1、AFP水平差异无统计学意义（P>0.05）。GP73+Dickkopf-1+AFP对肝细胞癌诊断的灵敏度、特异性、阳性预测值、阴性预测值、准确率均高于GP73、Dickkopf-1、AFP的诊断结果，差异有统计学意义（P<0.05）。结论：血清GP73、Dickkopf-1、AFP在肝细胞癌中呈高表达水平，三者联合可明显提高对肝细胞癌的诊断价值，临床有重要的参考价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the diagnostic value of serum GP73 combined with Dickkopf-1 and AFP in hepatocellular carcinoma. Methods: 117 cases of hepatocellular carcinoma in our hospital were collected as hepatocellular carcinoma group, 80 patients with hepatitis B virus as the hepatitis group, and randomly selected 80 healthy subjects as the control group from September 2014 to September 2016. The serums GP73, Dickkopf-1, AFP level of every group were detected by the enzyme-linked immunosorbent assay (ELISA), and the relationship between the GP73, Dickkopf-1, AFP between clinicopathological features were analyzed, the diagnostic value of GP73, Dickkopf-1 and AFP in hepatocellular carcinoma were analyzed. Results: The serums GP73, Dickkopf-1, AFP level of hepatocellular carcinoma group were higher than those of hepatitis group, control group, and the serum AFP level of hepatitis group was higher than that of control group, the difference was statistically significant (P<0.05). The GP73, Dickkopf-1, AFP in patients with classification B~C were higher than those in classification A among the Child Pugh classification, the difference was statistically significant (P<0.05). No statistical significance on difference of GP73, Dickkopf-1, AFP between different differentiation, tumor size,number of tumors was found (P>0.05). The sensitivity, specificity, positice predictive value, negative predictive value, and accuracy of GP73+Dickkopf-1+AFP in the diagnosis of hepatocellular carcinoma were higher than those of GP73, Dickkopf-1, AFP respectively, the difference was statistically significant (P<0.05). Conclusion: Serums GP73, Dickkopf-1, AFP in patients with hepatocellular carcinoma have high expression levels, combined with the three indicators can obviously improve the diagnostic value of hepatocellular carcinoma, which has clinically important reference value. |
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