| 鹿亚平,徐 勇,李 芳,李云芳,储 莉.不同剂量瑞舒伐他汀钙对老年冠心病合并高脂血症患者血脂水平的影响分析[J].,2017,17(26):5100-5102 |
| 不同剂量瑞舒伐他汀钙对老年冠心病合并高脂血症患者血脂水平的影响分析 |
| Analysis of Effects of Different Doses of Rosuvastatin Calcium on Serum Lipids in Elderly Patients with Coronary Heart Disease and Hyperlipidemia |
| 投稿时间：2017-03-13 修订日期：2017-04-09 |
| DOI：10.13241/j.cnki.pmb.2017.26.021 |
| 中文关键词: 瑞舒伐他汀 不同剂量 冠心病 高血脂症 血脂水平 |
| 英文关键词: Rosuvastatin Different doses Coronary heart disease Hyperlipidemia Blood lipid level |
| 基金项目:全军科研重点基金项目(AWS14R010-1) |
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| 中文摘要: |
| 摘要 目的：探讨在瑞舒伐他汀不同剂量下对治疗对冠心病合并高血脂症的老年患者的血脂功能水平的影响。方法：回顾性选取我院接诊的冠心病老年患者120例，且经过血脂检查全部属于高血脂症，按照使用瑞舒伐他汀的剂量不同，分为三组各40例患者，分别给予剂量为5 mg、10 mg和20 mg，以治疗后2个月为观察期，比较治疗前后患者的血脂水平变化及临床有效率。结果：①20 mg组患者的血脂水平HDL-C[(1.17±0.62) mmol/L]比其他两组明显上升，LDL-C[(3.67±0.83) mmol/L]、TC[(4.36±0.96) mmol/L]、TG[(1.68±0.94) mmol/L]也下降较另外两组明显(P均＜0.05)；②20 mg组的治疗有效率为(97.5%)明显高于5mg组(87.5%)和10mg组(85.0%) (P均＜0.05)。结论：瑞舒伐他汀治疗冠心病合并高血脂症的老年患者，选择20 mg剂量可显著改善患者的血脂水平，且具有较高的治疗有效率，是一种使用方便，临床效果明显的给药方式。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of different doses of rosuvastatin on lipid levels in elderly patients with CHD complicated with hyperlipidemia. Methods: 120 elderly patients with coronary heart disease admitted in our hospital were retrospectively chosen. By lipid examination, they were all hyperlipidemia. According to the dose of rosuvastatin, they were divided into three groups, and 40 cases in each group. They were given 5 mg, 10 mg and 20 mg treatment, respectively. After 2 months, the changes of blood lipid level and the clinical effective rate were compared before and after the treatment. Results:①The blood lipid levels HDL-C [(1.17 ± 0.62) mmol / L] was significantly higher than the other two groups. LDL-C [(3.67 ± 0.83) mmol / L], TC [(4.36 ± 0.96) mmol / L] and TG [(1.68 ± 0.94) mmol / L] were significantly lower than those of the other two groups (P <0.05). ②The effective rate of treatment in the 20mg group (97.5%) was significantly higher than that in the 5mg group (87.5%) and the 10mg group(85.0%). Conclusion: Rosuvastatin can treat coronary heart disease complicated with hyperlipidemia in elderly patients. The dosage of 20 mg can improve the blood lipid level of the patients, is an effective and convenient method, and with high therapeutic efficiency. |
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