| 谷莉娜,李根英,邢丽楠,冯 跃,张云艳.c-Src在上皮性卵巢癌组织中的表达及意义[J].,2017,17(26):5022-5028 |
| c-Src在上皮性卵巢癌组织中的表达及意义 |
| Expression and Clinical Significance of c-Src in the Epithelial Ovarian Carcinoma |
| 投稿时间：2017-04-10 修订日期：2017-04-30 |
| DOI：10.13241/j.cnki.pmb.2017.26.005 |
| 中文关键词: 细胞肉瘤蛋白 上皮性卵巢癌 预后 临床意义 |
| 英文关键词: Cell sarcoma Epithelial ovarian carcinoma Prognosis Clinical significance |
| 基金项目:国家自然科学基金项目（81372786）；黑龙江省教育厅科研基金项目（12541371） |
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| 中文摘要: |
| 摘要 目的：探讨上皮性卵巢癌组织中细胞肉瘤蛋白(Cell sarcoma，c-Src)的表达及其其临床意义。方法：通过Western blotting方法检测4例正常卵巢组织及21例上皮性卵巢组织中c-Src蛋白的表达。同时，通过免疫组化的方法检测26例正常卵巢组织和134例上皮性卵巢癌组织中c-Src的表达。统计分析c-Src的表达与上皮性卵巢肿瘤的临床病理因素之间的关系。结果：与正常卵巢组织相比，上皮性卵巢癌组织中c-Src蛋白的表达明显增高。c-Src蛋白的过表达与上皮性卵巢癌患者的临床病理分期、组织学分化程度、淋巴结转移情况及肿瘤复发之间差异存在统计学意义(P<0.05)，但与患者的年龄等因素均无显著相关性(P>0.05)。此外，c-Src蛋白的高表达，与上皮性卵巢癌患者的预后密切相关(P<0.05)。结论：c-Src在上皮性卵巢癌组织中过表达，且与肿瘤的恶性生物学行为密切相关，可能作为评估上皮性卵巢癌恶性程度、病情进展的重要指标及分子靶向疗法的新靶点。 |
| 英文摘要: |
| ABSTRACT Objective: we aim to determine the relationship between Cell sarcoma (c-Src) expression in patients with EOC and the disease phenotype. Methods: c-Src expression was evaluated using Western blotting analysis in 21 ovarian carcinomas and 4 normal ovarian tissues. Immunohistochemistry was used to evaluate c-Src expression in 134 ovarian carcinomas and 26 normal ovarian tissues. The association between c-Src expression and clinically pathologic characteristics were also assessed in these patients. Results: Our results indicated elevated c-Src protein in EOCs compared with that in normal tissues. The overexpression of c-Src was significantly associated with aggressive features, such as advanced disease stage, poor histological grade, lymph node metastasis, and tumor recurrence(P<0.05). In addition, the overexpression of c-Src is significantly associated with EOCs' prognosis. Conclusion: c-Src overexpression was significantly associated with the malignant biological behavior of tumor, suggesting c-Src as a potential preventive target in these patients. |
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