| 苗 青,曲彦隆,王 强,赵云龙,孙清泉.肌腱组织工程研究进展[J].,2017,17(24):4794-4797 |
| 肌腱组织工程研究进展 |
| The Investigative Progress of Tendon Engineering |
| 投稿时间：2016-10-23 修订日期：2016-11-18 |
| DOI：10.13241/j.cnki.pmb.2017.24.046 |
| 中文关键词: 组织工程 种子细胞 支架 力学刺激 |
| 英文关键词: Tissue engineering Seed cells Scaffold Mechanical stimulation |
| 基金项目:黑龙江省自然科学基金项目（D201112） |
|
| 摘要点击次数: 284 |
| 全文下载次数: 237 |
| 中文摘要: |
| 摘要：随着人口的年龄和预期寿命的增加，尤其是在年轻的人群中，肌腱损伤将变得更加普遍。传统的肌腱修复方法有许多不足之处，其功能重建不能令人满意。组织工程是一个发展的领域，组织工程肌腱体外的构建和体内的应用技术逐渐成熟，为临床上治疗肌腱缺损提供了一种不需要自体肌腱移植而且更加有前景的途径。在肌腱组织工程的研究中所面临的挑战和未来的发展方向为：种子细胞，新型支架材料和力学刺激。近年来肌腱干细胞的发现为种子细胞的选择提供了新思路，力学刺激对组织工程肌腱的影响也逐渐成为热点。本文就组织工程肌腱研究中种子细胞、支架材料和力学刺激的进展做一综述，并对未来的发展进行展望。 |
| 英文摘要: |
| ABSTRACT: As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals. Though the traditional operative therapy for tendon lesion can relieve the suffering of patients, the functional reconstruction is usually not optimistic. Tissue engineering is an advancing field, as the technology of construction in vitro and application in vivo matures, that can provide a more promising approach for tendon repair without tendon autograft. Challenges and future directions in the field of tendon tissue engineering focusing on four key parameters: seed cells, novel scaffolds, and mechanical stimulation. Recently, the discovery of TDSCs (tendon-derived stem cells) provides new ideas for the selection of seed cells and effect of mechanical stimulation on the tendon tissue engineering has become a hot spot. This article provides a review of recent progress in research about seed cells, scaffolds and mechanical stimulation for tendon engineering, and also speculates on the development in the future. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
