| 于建平,党小军,郭 盼,幕军平,剌 梅.IAA、ICA及GADA联合检测对糖尿病分型的诊断价值[J].,2017,17(24):4759-4761 |
| IAA、ICA及GADA联合检测对糖尿病分型的诊断价值 |
| Diagnostic Value of Combined Detection of IAA, ICA and GADA in the Classification of Diabetes Mellitus |
| 投稿时间：2016-10-24 修订日期：2016-11-20 |
| DOI：10.13241/j.cnki.pmb.2017.24.039 |
| 中文关键词: 胰岛素自身抗体 胰岛细胞抗体 谷氨酸脱羧酶抗体 糖尿病分型 |
| 英文关键词: IAA ICA GADA Classification of diabetes mellitus |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨胰岛素自身抗体(IAA)、胰岛细胞抗体(ICA)及谷氨酸脱羧酶抗体(GADA)联合检测对糖尿病分型的诊断价值。方法：选择2015年6月～2016年6月在我院进行诊治的1型糖尿病患者30例为A组，2型糖尿病患者60例为B组，同期在我院进行体检健康者50例为C组，采用酶联免疫吸附法(ELISA)检测三组的IAA、ICA及GADA，比较三组的阳性检出率。结果：A组空腹血糖为(10.12±3.68) mmol/L，B组空腹血糖为(11.23±3.26) mmol/L，A组和B组的空腹血糖均明显高于C组(4.35±1.42 mmol/L)(P<0.05)，但A组和B组的空腹血糖相比无明显差异(P>0.05)；A组和B组的IAA、ICA及GADA单独和联合检测的阳性率均明显高于C组(P<0.05)，且A组的IAA、ICA及GADA单独和联合检测的阳性率明显高于B组(P<0.05)；IAA、ICA及GADA联合检测对1型和2型糖尿病的敏感性和特异性均明显高于单独检测(P<0.05)。结论：IAA、ICA及GADA联合检测对糖尿病分型具有较高的临床诊断价值。 |
| 英文摘要: |
| ABSTRACT Objective: To study the diagnostic value of combined detection of IAA, ICA and GADA in the classification of diabetes mellitus. Methods: 30 cases of patients with type 1 diabetes who were treated in our hospital from June 2015 to June 2016 were selected as A group, 60 cases of patients with type 2 diabetes were selected as B group, 50 cases of healthy people were selected as C group. The IAA, ICA and GADA of the three groups were detected by ELISA, and the positive rate of the three groups were compared. Results: The fasting glucose of A group was (10.12±3.68) mmol/L, B group was (11.23±3.26) mmol/L, A group and B group were significantly higher than that of C group (P<0.05), but there was no significant difference between A group and B group (P>0.05); the positive rates of GADA, ICA and IAA in A group and B group were significantly higher than those in C group (P<0.05), and the positive rates of GADA, ICA and IAA in A group were significantly higher than those in B group (P<0.05); the sensitivity and specificity of combined detection of IAA, ICA and GADA in type 2 and type 1 diabetes mellitus were significantly higher than that in the single test (P<0.05). Conclusion: The combined detection of IAA, ICA and GADA has a high diagnostic value in the classification of diabetes mellitus, which is worth clinical application. |
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