| 程延娜,庞 静,安 智,霍永波,贺晓莉.前列地尔联合益肾化湿颗粒对糖尿病肾病患者血糖、血脂、肾功能以及尿足细胞相关蛋白的影响[J].,2017,17(24):4714-4718 |
| 前列地尔联合益肾化湿颗粒对糖尿病肾病患者血糖、血脂、肾功能以及尿足细胞相关蛋白的影响 |
| Effects of Alprostadil and Yishen Huashi on Blood Glucose, Blood Lipid, Renal Function and Urinary Podocyte Proteins of Patients with Diabetic Nephropathy |
| 投稿时间：2017-02-04 修订日期：2017-02-27 |
| DOI：10.13241/j.cnki.pmb.2017.24.028 |
| 中文关键词: 糖尿病肾病 前列地尔 益肾化湿颗粒 血糖 血脂 肾功能 尿足细胞相关蛋白 |
| 英文关键词: Diabetic nephropathy Alprostadil Yishen huashi particles Blood glucose Blood lipid Renal function Urinary podocyte related proteins |
| 基金项目:陕西省科技攻关项目(2005K10-G65) |
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| 中文摘要: |
| 摘要 目的：分析前列地尔联合益肾化湿颗粒对糖尿病肾病患者血糖、血脂、肾功能以及尿足细胞相关蛋白的影响。方法：98例糖尿病肾病患者按抽签法分为对照组与实验组，各49例，对照组予以前列地尔治疗，实验组基于对照组加用益肾化湿颗粒治疗，比较两组疗效，糖化血红蛋白（HbA1c）、血糖（FPG）、餐后2 h血糖低（2h PG），甘油三脂（TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C），血尿素氮（BUN）、肌酐（Cr）、β2微球蛋白（β2-MG）、胱抑素（Cys-C），尿足细胞标志蛋白（PCX）nephrin，安全性。结果：实验组总有效率高于对照组（P<0.05）。治疗后，两组HbAlc、FPG、2hPG比较无差异（P>0. 05）。实验组TG、TC、LDL-C、BUN、Cr、β2-MG、Cys-c、PCX、尿nephrin/尿Cr低于对照组（P<0.05）。实验组HDL-C高于对照组（P<0.05）。结论：前列地尔联合益肾化湿颗粒治疗对糖尿病肾病的疗效确切，可利于血糖、血脂、肾功能的改善，降低尿足细胞相关蛋白的浓度。 |
| 英文摘要: |
| ABSTRACT Objective: To analysis the effects of alprostadil and yishen huashi particles on blood glucose, blood lipid, renal function and urinary podocyte proteins of patients with diabetic nephropathy. Methods: 98 patients with diabetic nephropathy were selected and randomly divided into the control group and the experimental group with 49 cases in each group. The patients in the control group were treated with alprostadil, while the patients in the experimental group were treated with yishenhuashui particles on the basis of the control group. Then the curative effect, the levels of glycosylated hemoglobin (HbAlc), blood glucose (FPG), 2 h postprandial blood glucose (2h PG), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low density lipoprotein (LDL-C), blood urea nitrogen (BUN), creatinine (Cr), β2 microglobulin (β2 - MG), bladder inhibition (Cys-C) and urinary podocyte proteins (PCX) in the two groups were observed and compared between the two groups before and after the treatment. Results: The total effective rate of experimental group was higher than control group (P<0.05). After treatment, there was no statistically significant difference about the HbA1c, FPG and 2 HPG between the two groups (P>0.05). After the treatment, the levels of TG, TC, LDL-C, BUN, Cr, β2 MG, Cys C, PCX and urinary nephrin/urine Cr of the experimental group were lower than those of the control group (P<0.05). The HDL-C of experimental group was higher than that of the control group (P<0.05). Conclusion: The curative is effect of alprostadil and yishen huashi particles in treatment diabetic nephropathy patients, can conducive to the improvement of blood glucose, blood lipid, renal function, reduce the concentration of urinary podocyte related proteins. |
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