| 汪 峰,强亚勇,张斌斌,郭 巍,靳永胜,贾军琪.腹腔镜前列腺癌根治术治疗前列腺癌的疗效及对患者血清激素水平的影响[J].,2017,17(24):4710-4713 |
| 腹腔镜前列腺癌根治术治疗前列腺癌的疗效及对患者血清激素水平的影响 |
| Curative Effects of Laparoscopic Radical Prostatectomy for Prostate Cancer and Its Effect on Serum Hormones Levels |
| 投稿时间：2017-02-10 修订日期：2017-02-28 |
| DOI：10.13241/j.cnki.pmb.2017.24.027 |
| 中文关键词: 前列腺癌 腹腔镜前列腺癌根治术 性激素 |
| 英文关键词: Prostate cancer Laparoscopic radical prostatectomy prostate cancer Hormone |
| 基金项目:陕西省自然科学基金国际合作资助项目(2005KW-15) |
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| 中文摘要: |
| 摘要 目的：分析腹腔镜前列腺癌根治术治疗前列腺癌的疗效及其对患者血清激素水平的影响。方法：选择86例前列腺癌患者为研究对象并按抽签法随机分为对照组与观察组，每组43例。对照组行开放前列腺癌根治术治疗，观察组采用腹腔镜前列腺癌根治术，比较两组手术指标，手术前后血清促卵泡激素(FSH)、黄体生成素(LH)、双氢睾酮(DHT)、游离睾酮(FT)、总睾酮(T)、前列腺特异性抗原(T-PSA、F-PSA)，CD3+、CD4+、CD8+、CD4+/CD8+水平的变化及术后并发症的发生情况。结果：观察组手术时间明显长于对照组，失血量、肠功能恢复时间、住院时间、疼痛评分均明显低于或短于对照组(P<0.05)。两组治疗前后血清FSH、LH、DHT、FT、T、T-PSA、F-PSA比较差异均无统计学意义(P>0.05)。观察组CD3+、CD4+、CD4+/CD8+显著高于对照组(P<0.05)，CD8+低于对照组(P<0.05)。观察组术后并发症的发生率明显低于对照组(P<0.05)。结论：腹腔镜前列腺癌根治术可起到与开放手术相似的控瘤效果，提高血清雄激素水平和患者的免疫功能，控制肿瘤进展，且安全性更高。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the curative effects of laparoscopic radical prostatectomy for the prostate cancer and the its effect on the level serum hormones levels. Methods: 86 patients with prostate cancer were selected and divided into the control group and the observation group with 43 cases in each group according to the draw method. The control group was treated by open radical prostatectomy, while the observation group was treated by laparoscopic radical prostatectomy. The operation indicators, serum follicle stimulating hormone (FSH), luteinizing hormone (LH), dihydrotestosterone (DHT), free testosterone (FT), total testosterone (T), prostate specific antigen (T-PSA, F-PSA) levels, CD3+, CD4+, CD8+, CD4+/CD8+ before and after the surgery as well as the occurrence of postoperative complications were compared between two groups. Results: The operation time of observation group was significantly longer than that of the control group, and the blood loss, bowel function recovery time, hospital stay, pain scores of observation group was significantly lower or shorter than those of the control group(P<0.05). No significant difference was found in the serum FSH, LH, DHT, FT, T, T-PSA ,F-PSA levels before and after the surgery between two group(P>0.05). The CD3+, CD4+, CD4+/CD8+ of observation group was significantly higher than those of the control group (P<0.05), the CD8+ of observation group was lower than that of the control group(P< 0.05). The incidence rate of postoperative complication in the observation group was significantly lower than that of the control group (P<0.05). Conclusion: Laparoscopic radical prostatectomy could play a similar effect with the open surgery on the tumor control, it could improve the level of serum testosterone, immune function with high safety. |
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