| 徐 林,江从兵,程 伟,徐 平,张建军.连续性血液净化对多发伤并发脓毒症患者炎症状态及免疫功能的影响[J].,2017,17(24):4691-4694 |
| 连续性血液净化对多发伤并发脓毒症患者炎症状态及免疫功能的影响 |
| Effect of Continuous Blood Purification on Inflammatory State and Immune Response in Patients with Multiple Injury and Sepsis |
| 投稿时间：2016-12-03 修订日期：2016-12-27 |
| DOI：10.13241/j.cnki.pmb.2017.24.022 |
| 中文关键词: 脓毒症 连续性血液净化 炎症状态 免疫功能 凝血功能 |
| 英文关键词: Sepsis Continuous blood purification Inflammation state Immune function Blood coagulation function |
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| 中文摘要: |
| 摘要 目的：探讨连续性血液净化对多发伤并发脓毒症患者炎症状态及免疫功能的影响。方法：选择2015年1月至2016年5月在我院接受治疗的88例多发伤并发脓毒症患者作为研究对象，按照随机数字表法分为对照组（n=44）和观察组（n=44），对照组给予常规治疗，观察组给予连续性血液净化治疗，治疗3 d后观察两组患者的急性生理学与慢性健康状况 Ⅱ( APACHEⅡ) 评分，采用酶联免疫吸附法（ELISA）检测血清白介素-2（IL-2）、白介素-4（IL-4）、白介素-10（IL-10）和干扰素-γ（IFN-γ）含量，流式细胞仪分析CD3+、CD4+、CD8+及NK细胞水平，全自动生化分析仪检测尿素氮( BUN) 、血肌酐( Scr)、凝血酶原时间( PT) 、凝血酶时间( TT) 、活化部分凝血活酶时间( APTT) 。结果：观察组患者APACHEⅡ评分、BUN和Scr水平均低于对照组（P<0.05）。观察组患者IL-2、IL-4、IL-10和IFN-γ含量均低于对照组（P<0.05）。观察组患者CD3+、CD4+、CD8+及NK水平高于对照组（P<0.05）。观察组患者PT、TT、APTT均低于对照组（P<0.05）。结论：连续性血液净化对多发伤并发脓毒症患者具有较好的临床疗效，可减轻炎症反应，提高免疫功能，改善凝血功能。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of continuous blood purification on inflammatory state and immune response in patients with multiple injury and sepsis. Methods: 88 patients with multiple injury and sepsis who were treated in our hospital from January 2015 to May 2016 were selected as the research object, they were divided into the control group (n=44) and observation group (n=44) according to random number table method. The control group was given conventional treatment, and the observation group was given continuous blood purification treatment. The acute physiology and chronic health conditions Ⅱ(APACHE Ⅱ)score was observed in two groups Ⅱ at 3 d after treatment. The serum content of Interleukin -2(IL-2), Interleukin -4(IL-4), Interleukin -10(IL-10) and interferon -γ (IFN - γ) were detected by ELISA method. The levels of CD3 +, CD4 +, CD8 + and NK cell were analyzed by flow cytometry. The urea nitrogen (BUN), serum creatinine (Scr), prothrombin time (PT), thrombin time (TT), activated partial blood coagulation time (APTT) were tested by automatic biochemical analyzer. Results: The APACHE Ⅱ score, BUN and Scr levels in observation group were lower than the control group (P<0.05). The content of IL-2, IL-4, IL-10 and IFN-γ in observation group were lower than the control group (P<0.05). The levels of CD3+, CD4+, CD8+ and NK in observation group were higher than the control group (P<0.05). The levels of PT, TT and APTT in observation group were lower than the control group (P<0.05). Conclusion: Continuous blood purification in patients with multiple injury and sepsis had better clinical curative effect, can reduce inflammation, improve immune function and the function of blood coagulation. |
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