| 张 明,王西辉,解 飞,何鹏辉,谢素霖.阿托伐他汀对老年冠心病合并糖尿病患者的治疗效果及对血脂、尿酸水平的影响[J].,2017,17(23):4564-4567 |
| 阿托伐他汀对老年冠心病合并糖尿病患者的治疗效果及对血脂、尿酸水平的影响 |
| Effect of Atorvastatin on Blood Lipid and Uric Acid Levels of Elderly Patients with Coronary Heart Disease and Diabetes Mellitus |
| 投稿时间：2016-12-23 修订日期：2017-01-20 |
| DOI：10.13241/j.cnki.pmb.2017.23.039 |
| 中文关键词: 阿托伐他汀 冠心病 糖尿病 血脂 尿酸 |
| 英文关键词: Atorvastatin Coronary heart disease Diabetes mellitus Blood lipids Uric acid |
| 基金项目:陕西省教育厅专项基金项目（16JK1667）；西安医学院校级重点建设学科基金项目（16JK1667） |
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| 中文摘要: |
| 摘要 目的：探讨阿托伐他汀对老年冠心病合并糖尿病患者的治疗效果及对血脂、尿酸水平的影响。方法：收集我院就诊的116例冠心病合并糖尿病患者，随机分为对照组和实验组，每组各58例。两组患者入院后均给予控制血糖、降血压等对症治疗。对照组患者给予阿司匹林肠溶片0.3~0. 6g/次，3次/d，口服，氯吡格雷片2片/次，1次/d，口服，硝酸甘油0.25~0.5 g/次，3次/d，含服；实验组患者在对照组基础上给予阿托伐他汀片10~20 mg/次，1次/d，治疗连续4周，治疗期间根据患者情况及时调整药量。观察并比较两组患者治疗前后血清低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、总胆固醇(TC)、尿酸(UA)、糖化血红蛋白(HbA1c)水平以及临床疗效。结果：与治疗前相比，两组患者治疗后的血清LDL-C、TG、TC、UA、HbA1c水平均下降，HDL-C水平升高，差异具有统计学意义(P<0.05)；与对照组相比，实验组患者的LDL-C、TG、TC、UA、HbA1c水平较低，HDL-C水平及临床治疗有效率均较高，差异均具有统计学意义(P<0.05)。结论：阿托伐他汀能够有效降低老年冠心病合并糖尿病患者血糖、血脂以及尿酸水平，且临床治疗效果较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of atorvastatin on the blood lipid and uric acid levels of elderly patients with coro- nary heart disease complicated with diabetes mellitus. Methods: 116 patients with coronary heart disease and diabetes were randomly di- vided into the control group and the experimental group, 58 cases in each group. Both groups of patients were given blood glucose con- trol, blood pressure and other symptomatic treatment. The control group was treated with Aspirin Enteric-coated Tablets 0.3~0.6 g/times, 3 times/d, oral, clopidogrel tablets, 2 tablets each time, 1 time/d, oral, nitroglycerin, 0.25~0.5 g/time, 3 times/d, with service; the experi- mental group was given atorvastatin on the basis of control group, 10~20 mg/time, 1 time/d, treatment for 4 weeks. During the treatment, the dosage was timely adjusted according to the conditions of patients. The serum low density lipoprotein cholesterol (LDL-C), high den- sity lipoprotein cholesterol (HDL-C), triglyceride (TG), total cholesterol (TC), uric acid (UA), glycosylated hemoglobin (HbA1c) levels before and after treatment and the clinical treatment efficiency were observed and compared between two groups. Results: Compared with before treatment, the serum LDL-C, TG, TC, UA, HbA1c levels were decreased after treatment in both groups of patients, the HDL-C level was increased(P<0.05); compared with the control group, the serum LDL-C, TG, TC, UA, HbA1c levels were lower, HDL-C level was higher in the experimental group(P<0.05); compared with the control group, the effective rate of clinical treatment of the experimental group were higher(P<0.05). Conclusion: Atorvastatin could effectively reduce the blood glucose, blood lipid, uric acid levels of elderly patients with coronary heart disease complicated with diabetes. |
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