| 包小燕,李人立,张丽芸,井秋芳,李洪涛.二甲双胍联合门冬胰岛素对妊娠期糖尿病患者血清胆固醇、总胆红素、尿酸和尿微量蛋白水平及母婴结局的影响[J].,2017,17(23):4510-4513 |
| 二甲双胍联合门冬胰岛素对妊娠期糖尿病患者血清胆固醇、总胆红素、尿酸和尿微量蛋白水平及母婴结局的影响 |
| Effect of Metformin Combined with Insulin Aspart on Serum Cholesterol, Total Bilirubin, Uric Acid, Urinary Micro Protein Levels, Maternal and Infant Outcomes of Gravida with Gestational Diabetes Mellitus |
| 投稿时间：2016-12-27 修订日期：2017-01-21 |
| DOI：10.13241/j.cnki.pmb.2017.23.025 |
| 中文关键词: 妊娠期糖尿病 二甲双胍 门冬胰岛素 母婴结局 |
| 英文关键词: Gestational diabetes mellitus Metformin Insulin aspart Maternal and infant outcomes |
| 基金项目:青海省自然科学基金项目(20154-Z-203) |
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| 中文摘要: |
| 摘要 目的：探讨二甲双胍联合门冬胰岛素对妊娠期糖尿病患者血清胆固醇(TC)、总胆红素(TBil)、尿酸(UA)、尿微量蛋白(mAlb)水平及母婴结局的影响。方法：选择2014年6月至2016年6月我院接诊的84例妊娠期糖尿病患者，通过随机数表法分为观察组(n=42)和对照组(n=42)。在常规治疗基础上，对照组使用门冬胰岛素治疗，观察组再联合盐酸二甲双胍。比较两组治疗前后血糖指标、TC、TBil、UA、mAlb的变化以及母婴结局。结果：治疗后，观察组空腹血糖(FBG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、TC、UA、mAlb水平均显著低于对照组(P＜0.05)，TBil水平明显高于对照组(P＜0.05)，妊娠期高血压、羊水过多、早产、剖宫产、巨大儿、新生儿黄疸的发生率均显著低于对照组(P＜0.05)。结论：二甲双胍联合门冬胰岛素对妊娠期糖尿病患者的疗效显著，可有效改善患者血糖指标以及TC、TBil、UA、mAlb水平，改善母婴结局。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of metformin combined with insulin aspart on the serum cholesterol(TC), total Bilirubin(TBil), uric Acid(UA), urinary Micro Protein(mAlb) levels and Maternal and Infant Outcomes of gravida with Gestational Diabetes Mel- litus. Methods: 84 patients of gestational diabetes mellitus who received therapy from June 2014 to June 2016 in our hospital were selected. According to random number table, those patients were divided into the observation group (n=42) and the control group (n=42), on the basis of routine treatment, The control group was treated with insulin aspart, while the observation group was combined with metformin hydrochloride. The blood glucose index and the levels of TC, TBil, UA, mAlb and maternal and infant outcomes were compared. Results: After treatment, the levels of fasting blood glucose (FBG), postprandial 2h blood glucose (2hPG), glycosylated hemoglobin (HbA1c), TC, TBil, UA and mAlb in the observation group were significantly lower than the control group, the levels of TBil was signifi- cantly higher than the control group(P＜0.05); the incidence of gestational hypertension, hydramnios, premature birth, cesarean section, giant child and neonatal jaundice were significantly lower than the control group(P＜0.05). Conclusion: Metformin combined with in- sulin aspart was well for gestational diabetes mellitus, which could effectively improve the blood glucose indicators and TC, TBil, UA, mAlb levels, maternal and infant outcomes. |
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