| 楚文丽,宋立强,严蕊娜,王惠芳,牛攀霞,周 立.舒利迭联合无创正压通气治疗COPD合并呼吸衰竭的临床疗效观察[J].,2017,17(23):4483-4486 |
| 舒利迭联合无创正压通气治疗COPD合并呼吸衰竭的临床疗效观察 |
| Observation on the Clinical Effect of Seretide and Noninvasive Positive Pressure Ventilation on the COPD Combined with Respiratory Failure |
| 投稿时间：2017-03-06 修订日期：2017-03-30 |
| DOI：10.13241/j.cnki.pmb.2017.23.018 |
| 中文关键词: 慢性阻塞性肺疾病 Ⅱ型呼吸衰竭 舒利迭 无创正压通气 疗效 |
| 英文关键词: Chronic obstructive pulmonary disease Type 2 respiratory failure Seretide Noninvasive positive pressure ventilation Efficacy |
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| 中文摘要: |
| 摘要 目的：分析舒利迭联合无创正压通气治疗慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭的临床疗效。方法：选取于我院诊治的COPD合并Ⅱ型呼吸衰竭患者120例，随机均分为观察组和对照组。所有患者均予以常规、对症和支持治疗，在此基础上对照组予以无创正压通气(NIPPV)治疗，观察组在对照组的基础上加用舒利迭治疗。分析和比较两组患者治疗前后的动脉血气、炎性因子水平、肺功能和CAPS评分。结果：与治疗前相比，两组患者治疗后的pH、PaO2、SaO2水平均明显升高，PaCO2明显降低，血清IL-33、TNF-α、sICAM-1水平均明显降低，FVC、PEFR、FEV1%、FEV1/FVC水平均明显升高，CAPS评分明显下降，且观察组的上述指标变化均较对照组更为明显(P＜0.05)。结论：舒利迭联合NIPPV能够较单用NIPPV更有效降低COPD合并Ⅱ型呼吸衰竭患者炎性因子水平，改善血气和肺功能。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinical efficacy of Seretide combined with noninvasive positive pressure ventilation (NIP- PV) in the treatment of chronic obstructive pulmonary disease (COPD) complicated with type 2 respiratory failure (RF). Methods: 120 patients of COPD complicated with type 2 RF were randomly divided into the observation group and the control group. All patients were treated with routine, symptomatic and supportive treatment, based on that NIPPV was used in the control group, and the observation group was treated with Seretide on the basis of NIPPV. The levels of arterial blood gas, inflammatory factors, pulmonary function and CAPS score before and after treatment were compared and analyzed. Results: After treatment, the pH, PaO2 and SaO2 of both groups were significantly increased, PaCO2 levels weresignificantly decreased, serum IL-33, TNF-α and sICAM-1 levels were significantly de- creased, FVC, PEFR, FEV1% and FEV1/FVC were significantly decreased, and the CAPS scores were significantly decreased; the changes of all the index mentioned above in the observation group were more statistically significant (P<0.05). Conclusion: Seretide com- bined with NIPPV could more effectively decrease the levels of inflammatory factors and improve the blood gas and lung function in the patients of COPD with type 2 respiratory failure. |
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