| 刘学嘉,季 洋,赵青松,曹绍东,付培德,侯学敬,张 同.弥散加权成像及1H磁共振波谱在新生儿缺氧缺血性脑病中的诊断价值[J].,2017,17(23):4475-4478 |
| 弥散加权成像及1H磁共振波谱在新生儿缺氧缺血性脑病中的诊断价值 |
| Diagnostic Value of Diffusion Weighted Imaging and 1H Magnetic Resonance Spectroscopy for the Neonates with Hypoxic Ischemic Encephalopathy |
| 投稿时间：2017-01-11 修订日期：2017-01-30 |
| DOI：10.13241/j.cnki.pmb.2017.23.016 |
| 中文关键词: 弥散加权成像 1H磁共振波谱 新生儿 缺氧缺血性脑病 |
| 英文关键词: Diffusion weighted imaging 1H magnetic resonance spectroscopy Neonate Hypoxic ischemic encephalopathy |
| 基金项目:黑龙江省卫生计生委科研课题（2016-132） |
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| 中文摘要: |
| 摘要 目的：探讨弥散加权成像、1H磁共振波谱诊断新生儿缺氧缺血性脑病的应用价值。方法：以本院收治的缺氧缺血性脑病新生儿37例为研究组，另选择健康新生儿40例作为对照组，两组新生儿均接受弥散加权成像及1H磁共振波谱检查，观察研究组新生儿普通MRI与弥散加权成像检查结果，对比研究组和对照组新生儿的脑代谢化合物相对浓度。结果：与普通MRI检出率相比，研究组患儿的弥散加权成像信号明显升高，差异存在统计学意义(P＜0.05)。研究组NAA/Cr比值低于对照组，Cho/Cr、MI/Cr、Glu-Gln/Cr、Lac/Cr比值高于对照组，差异存在统计学意义(P＜0.05)。结论：临床上诊断新生儿缺氧缺血性脑病时，弥散加权成像与1H磁共振波谱的联合应用可提升诊断准确率，通过对代谢物浓度的分析有利于评价缺氧缺血导致脑组织损害的严重程度。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the diagnostic value of diffusion weighted imaging and 1H magnetic resonance spectroscopy for the neonatal hypoxic ischemic encephalopathy (HIE). Methods: 37 cases of patients with neonatal hypoxic ischemic encephalopathy admitted in our hospital were selected as the study group, another 40 healthy neonates were selected as the control group, both groups of neonates underwent diffusion-weighted imaging and 1H magnetic resonance spectroscopy, ordinary MRI and diffusion weighted imaging findings of neonates in the study group were observed, the neonatal cerebral metabolic compounds relative concentration were observed and compared between two groups. Results: The detection rate of diffusion-weighted imaging was significantly higher compared with the ordinary MRI(P<0.05). The relative ratio of brain metabolic compounds NAA/Cr of study group were obviously lower than those of the control group, while the Cho/Cr, MI/Cr, Glu-Gln/Cr, Lac/Cr were significantly higher (P<0.05). Conclusion: Diffusion weighted imaging combined with 1H magnetic resonance spectroscopy could improve the diagnostic accuracy of neonatal hypoxic ischemic encephalopa- thy, the analysis of the concentrations of brain metabolic compounds could contribute to evaluate the severity of HIE. |
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