| 唐诗慧,范 维,张 政,王 萍,邓巧玲,许培培,王俊娥,喻明霞.肿瘤坏死因子-α在乳腺肿瘤中的表达及其与影像学特征的关系[J].,2017,17(23):4406-4411 |
| 肿瘤坏死因子-α在乳腺肿瘤中的表达及其与影像学特征的关系 |
| The Expression of Tumor Necrosis Factor Alpha in Breast Neoplasms and Its Relationship with Imaging Manifestations |
| 投稿时间：2017-02-25 修订日期：2017-03-17 |
| DOI：10.13241/j.cnki.pmb.2017.23.002 |
| 中文关键词: 肿瘤坏死因子α 乳腺肿瘤 影像学特征 |
| 英文关键词: TNF-α Breast cancer Imaging |
| 基金项目:国家自然科学基金项目(81472033, 30901308)；湖北省自然科学基金项目(2013CFB233, 2013CFB235)；武汉市科技攻关项目(2014060101010045)；卫生厅青年人才项目(WJ2015Q021)；武汉大学中南医院科技创新孵育基金项目(ZNPY2016054) |
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| 中文摘要: |
| 摘要 目的：检测乳腺肿瘤中肿瘤坏死因子α(Tumor necrosis factor alpha，TNF-α)表达及其与影像学特征的关系。方法：利用免疫荧光和流式细胞术检测MDA-MB-231及MCF-7乳腺癌细胞中TNF-α的表达；收集82例经病理证实的乳腺疾病患者组织及其病理资料、影像学资料，通过免疫组化检测乳腺组织TNF-α的表达，并分析其表达量与病理特征及影像学特征之间的关系。结果：TNF-α在MDA-MB-231细胞中呈高表达，恶性乳腺肿瘤组织中TNF-α的表达显著高于乳腺良性肿瘤，其表达量与淋巴结转移、TNM分期相关、核磁共振(MRI)强化是否均匀、钼靶X射线的边界的平滑度形状是否规则以及B超中彩色血流信号强弱均显著相关(P<0.05)。结论：乳腺肿瘤组织中TNF-α呈异常高表达，且与乳腺肿瘤的某些影像学特征密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To detect the expression of tumor necrosis factor alpha in (TNF alpha) breast cacner and its relationship with imaging features. Methods: Using immunofluorescence and flow cytometry to detect the expression of TNF-α in MDA-MB-231 and MCF-7. Collect 82 patients with mammary gland disease, which was confirmed by pathological tissue, its pathological data, imaging data, and by immunohistochemistry to detect the expression of TNF-α in breast tissues, and analyze and the relationship between its ex- pression and the pathological features and imaging characteristics. Results: TNF-α high expression in MDA-MB-231, the expression of TNF-α in malignant breast tumor tissue significantly higher than that in benign tumor, the expression quantity associated with lymph node metastasis, TNM stages, strengthen uniform in MRI, the boundary and the shape of the X-ray Mammography (P=0.01), and color flow signal strength in ultrasound (P<0.05). Conclusion: TNF alpha in breast tumor tissue was unusually high expression, and is closely related to some of the imaging features of breast tumor. |
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