| 刘晨亮,王惠玲,杨 芳,梁师浪,金 亮.重复经颅磁刺激对慢性精神分裂症患者认知功能影响的初步研究[J].,2017,17(22):4372-4375 |
| 重复经颅磁刺激对慢性精神分裂症患者认知功能影响的初步研究 |
| Preliminary Study of Effect of Repetitive Transcranial Magnetic Stimulation on Cognitive Function in Patients with Chronic Schizophrenia |
| 投稿时间：2016-11-12 修订日期：2016-11-30 |
| DOI：10.13241/j.cnki.pmb.2017.22.042 |
| 中文关键词: 重复经颅磁刺激 慢性精神分裂症 认知功能 |
| 英文关键词: Repetitive transcranial magnetic stimulation Chronic schizophrenia Cognitive function |
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| 中文摘要: |
| 摘要 目的：探讨重复经颅磁刺激(rTMS)对慢性精神分裂症患者认知功能的影响。方法：100例慢性精神分裂症患者，按照随机数字表法分为rTMS真刺激组和伪刺激组，每组各50例。采用阳性与阴性症状量表(PANSS)及副反应量表(TESS)评估患者治疗前后精神症状及不良反应；采用威斯康星卡片分类测验(WCST)及可重复的成套神经心理状态测量(RBANS)评价患者治疗前后认知功能。结果：治疗后，rTMS真刺激组PANSS总分、阳性量表分、阴性量表分、一般精神病理量表分均明显降低（P＜0.05），且均明显低于伪刺激组（P＜0.05），两组治疗前后及组间TESS评分无明显差异（P＞0.05）；rTMS真刺激组WCST中的概念化水平百分数明显高于伪刺激组（P＜0.05），总时间及错误思考时间短于伪刺激组（P＜0.05）；rTMS真刺激组RBANS中视觉广度与延迟记忆成绩明显提高（P＜0.05），且视觉广度明显高于伪刺激组（P＜0.05）；rTMS真刺激组2例患者首次治疗后出现轻度不适症状，随访3个月所有患者均无不适主诉。结论：rTMS治疗对慢性精神分裂症患者的部分认知功能有一定的改善作用，且安全性较高，值得进一步研究。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in patients with chronic schizophrenia. Methods: 100 cases patients with chronic schizophrenia weree selected.They were divided into rTMS stimulation group and pseudo stimulation group according to the random number table method, and each group include 50 cases.The positive and Negative Syndrome Scale (PANSS) and the Treatment Emergent Symptom scale (TESS) were used to assess the clinical symptoms and side effects before and after the treatment; The Wisconsin Card Sorting Test (WCST) and Repeatable Neuropsychological State Measurement (RBANS) were used to assess the patients' cognitive function before and after treatment. Results: After treatment,the PANSS total score, the positive subscale score,the negative subscale score,the general psychopathological subscale score in the rTMS stimulation group were significantly reducing (P<0.05), and significantly lower than those in the pseudo stimulation group (P<0.05), but the TESS scores between the two groups did not differ significantly before and after treatment.The percentage of WCST in rTMS stimulation group was significantly higher than that in the pseudo stimulation group (P<0.05), and the total time and wrong thinking time was shorter than that in the pseudo stimulation group (P<0.05); The visual span and delayed memory performance of RBANS was significantly increased in the rTMS stimulation group (P<0.05), and the visual span was significantly higher than that in the pseudo stimulus group (P<0.05); There were 2 cases of patients with mild symptoms after the first treatment in RTMS stimulation group, all patients were without complaint followed up for 3 months. Conclusion: rTMS treatment on the part of the cognitive function of patients with chronic schizophrenia has a certain improvement effect, and higher security, it is worth further study. |
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