| 段礼鹏,马国驹,赵合意,张 静,张文波,高 飞.内外联合固定术治疗骨盆骨折的临床疗效及对血清ALP, TNF-α,TGF-β水平的影响[J].,2017,17(22):4338-4341 |
| 内外联合固定术治疗骨盆骨折的临床疗效及对血清ALP, TNF-α,TGF-β水平的影响 |
| Clinical Effect of Internal Combined with External Fixation on Pelvic Fracture and Serum ALP, TNF-α and TGF-β Levels |
| 投稿时间：2017-01-13 修订日期：2017-01-30 |
| DOI：10.13241/j.cnki.pmb.2017.22.033 |
| 中文关键词: 内外固定术 骨盆骨折 血清碱性磷酸酶 肿瘤坏死因子-α 转化生长因子-β |
| 英文关键词: Internal and external fixation Pelvic fracture Alkaline phosphatase Tumor necrosis factor-α Transforming growth factor-β |
| 基金项目:河北省卫生和计生委科研计划项目（20160287） |
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| 中文摘要: |
| 摘要 目的：研究内外联合固定术治疗骨盆骨折的临床观疗效及对血清碱性磷酸酶(ALP)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β(TGF-β)水平的影响。方法：选取2014年8月至2015年7月本院收治的86例骨盆骨折患者，根据入院顺序分为观察组和对照组，43例每组。对照组使用常规内固定术，观察为内外联合固定术。分析两组患者临床疗效、手术情况、并发症的发生情况，比较两组患者治疗前后血清ALP、TNF-α、TGF-β水平的变化。结果：治疗后，观察组的优良率显著高于对照组[81.40%(35/43)比41.86%(18/43)](P<0.05)，手术时间、术中出血量、骨折愈合时间显著短于或少于对照组(P<0.05)。治疗前，两组患者血清ALP、TNF-α、TGF-β水平比较无显著性差异(P>0.05)；治疗后，两组患者血清ALP水平显著高于治疗前(P<0.05)，TNF-α、TGF-β水平较治疗前显著降低(P<0.05)，其中观察组的ALP水平明显比对照组高(P<0.05)，TNF-α、TGF-β水平明显比对照组低(P<0.05)。观察组的并发症发生率明显低于对照组[0.00%(0/43)比11.63%(5/43)](P<0.05)。结论：内外联合固定术治疗骨盆骨折患者的临床疗效和安全性均较高，可有效升高患者血清ALP水平，降低TNF-α、TGF-β水平。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical effect of internal combined with external fixation in the treatment of pelvic fracture and its effect on the serum alkaline phosphatase (ALP), tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β). Methods: Eighty-six patients with pelvic fractures admitted in our hospital from August 2014 to July 2015 were selected and divided into the observation group and control group according to the admission order. Conventional internal fixation was used in the control group, and the internal combined with external fixation was performed in the observation group. The clinical curative effect, operative time, blood loss, fracture healing time and incidence of complication were compared between two groups. The levels of serum ALP, TNF-α and TGF-β in the two groups were compared before and after treatment between two groups. Results: The excellent rate of observation group was significantly higher than that of the control group [81.40% (35/43) vs 41.86% (18/43)] (P <0.05). The operative time, blood loss and fracture healing time in the observation group were significantly shorter or less than those of the control group(P<0.05). There was no significant difference in the serum ALP, TNF-α and TGF-β levels between the two groups before treatment (P>0.05). After treatment, the serum ALP levels in the two groups were significantly higher than before treatment(P<0.05). The levels of TNF-α and TGF-β were significantly lowe than those before treatment(P<0.05), the ALP levels in the observation group was significantly higher than that of the control group (P <0.05), and the levels of TNF-α and TGF-β were significantly lower than those of the control group 0.05). The incidence of complications of observation group was significantly lower than that of the control group [0.00% (0/43) vs 11.63% (5/43)] (P <0.05). Conclusion: Internal and external fixation was effective and safe in the treatment of pelvic fractures, which could significantly increase the serum ALP level and reduce the levels of TNF-α and TGF-β. |
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