| 杨新凤,王会荣,田 浩,聂国明,邹敏书.过敏性紫癜患儿血清IL-21，TGF-β1，TNF-α及IgA1水平与紫癜性肾炎发生的相关性研究[J].,2017,17(22):4295-4298 |
| 过敏性紫癜患儿血清IL-21，TGF-β1，TNF-α及IgA1水平与紫癜性肾炎发生的相关性研究 |
| Correlation of Serum Levels of IL-21, TGF-β1, TNF-α and IgA1 in Children with Allergic Purpura and Occurrence of Purpura Nephritis |
| 投稿时间：2016-12-28 修订日期：2017-01-21 |
| DOI：10.13241/j.cnki.pmb.2017.22.022 |
| 中文关键词: 过敏性紫癜 紫癜性肾炎 白细胞介素-21 转化生长因子-β1 肿瘤坏死因子-α 免疫球蛋白A1 |
| 英文关键词: Allergic purpura Purpura nephritis Interleukin-21 Transforming growth factorβ1 Tumor necrosis factor-α Immunoglobulin A1 |
| 基金项目:湖北省医学科学研究重点计划项目（20120370） |
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| 中文摘要: |
| 摘要 目的：探讨过敏性紫癜患儿血清白细胞介素-21（IL-21）、转化生长因子-β1（TGF-β1）、肿瘤坏死因子-α（TNF-α）、免疫球蛋白A1（IgA1）与紫癜性肾炎发生的相关性。方法：选择我院2015年11月~2016年5月收治的57例过敏性紫癜患儿，其中29例普通过敏性紫癜患儿，28例紫癜性肾炎，同期选择30例健康体检儿童作为对照组。观察并比较三组患儿血清IL-21，TGF-β1，TNF-α，IgA1，免疫球蛋白A（IgA），补体C3及C4水平。结果：过敏性紫癜肾炎组IL-21，TGF-β1，TNF-α，IgA1及IgA高于普通过敏性紫癜组，差异有统计学意义（P<0.05）；普通过敏性紫癜组IL-21，TGF-β1，TNF-α，IgA1及IgA高于对照组（P<0.05）；过敏性紫癜组IL-21，TGF-β1，TNF-α，IgA1及IgA高于对照组（P<0.05）。三组患儿补体C3及C4比较，差异无统计学意义（P>0.05）。结论：IL-21，TGF-β1，TNF-α及IgA1均参与过敏性紫癜及紫癜性肾炎的发生及发展过程。 |
| 英文摘要: |
| ABSTRACT Objective: To research the correlation of serum levels of IL-21, TGF-β1, TNF-α and IgA1 in children with allergic purpura and the purpura nephritis. Methods: 57 cases with allergic purpura who were treated in our hospital from November 2015 to May 2016 were selected and 29 cases were diagnosed with general allergic purpura, and another 28 cases were diagnosed with purpuric nephritis. 30 healthy children were selected as the control group. Then the serum levels of IL-21, TGF-β1, TNF-α, IgA1, immunoglobulin A (IgA), C3 and C4 between the three groups were observed and compared. Results: The serum levels of IL-21, TGF-β1, TNF-α, IgA1 and IgA in the purpuric nephritis group were higher than those of the control group and the general allergic purpura group, and the differences were statistically significant (P<0.05); The serum levels of IL-21, TGF-β1, TNF-α, IgA1 and IgA in the general allergic purpura group were higher than those of the control group, and the differences were statistically significant (P<0.05); There was no statistically significant difference about the C3 and C4 in the three groups (P>0.05). Conclusion: The serum levels of IL-21, TGF-β1, TNF-α and IgA1 may be involved in the development of henoch-schonlein purpura and purpura nephritis. |
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