| 贺 佳,孔东燕,蔡芳苗,宫淑杰,郑燕青,张小杨,罗明英.首次发病精神分裂症患者早期认知功能改变研究[J].,2017,17(22):4277-4280 |
| 首次发病精神分裂症患者早期认知功能改变研究 |
| The Changes of Neurocognitive Function in Early Stage in Patients with First-Episode Schizophrenia |
| 投稿时间：2016-10-31 修订日期：2016-11-30 |
| DOI：10.13241/j.cnki.pmb.2017.22.017 |
| 中文关键词: 精神分裂症 首次发病 认知功能 |
| 英文关键词: Schizophrenia First-episode Neurocognitive function |
| 基金项目:国家自然科学基金项目（81500377）；云南省科技厅-昆明医科大学联合专项（2015FB009） |
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| 中文摘要: |
| 摘要 目的：探讨首次发病精神分裂症患者早期认知功能损伤情况。方法：选取我院2015年1月~2016年1月收治的73例首次发病精神分裂症患者（研究组）和75例健康者（对照组）作为研究对象，采用神经心理测验工具评估两组对象认知功能并进行比较。结果：BVMT-R试验中研究组延迟回忆、回忆总数、3试、2试和1试得分均低于对照组，差异有统计学意义(P<0.05)。HVLT-R试验中研究组延迟总数、3试和2试得分均低于对照组，差异有统计学意义(P<0.05)。研究组沟槽钉板测验中利手与非利手耗时均高于对照组，连线测验中连线测验A、颜色连线1及2完成时间均高于对照组，差异均有统计学意义(P<0.05)。PASAT测试中研究组尝试数和正确数均低于对照组，差异有统计学意义(P<0.05)。WAIS-III测试中研究组符合搜索错误数目高于对照组，而符号搜索正确数目、符号搜索总分及数字符号分数均低于对照组，差异有统计学意义(P<0.05)。Stroop色词测验中研究组单词总数、颜色总数和色/词总数均低于对照组，差异有统计学意义(P<0.05)。WMS-III测验结果组间比较差异无统计学意义(P>0.05)。结论：首次发病精神分裂症患者早期认知功能广泛损伤。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the changes of neurocognitive function in early stage in patients with first-episode schizophrenia. Methods: In this study, 73 cases of patients with first-episode schizophrenia (research group) and 75 cases of health person (control group) were selected from January 2015 to January 2016 in our hospital. The neurocognitive function was evaluated by neuro-psychological testing tool and the data between two group were compared. Results: Scores of delayed recall, total recall, 3 trial, 2 trial and 1 trial of research group were lower than those of control group in BVMT-R test, and the difference was statistically significant (P<0.05). In HVLT-R test, the scores of total delay, 3 trial and 2 trial of research group were significantly lower than those of control group (P<0.05). The consuming time of dominant hands and subdominant hands in pegboard tasks were significantly higher in research group than in control group (P<0.05). Completion time of connection test A, color connection 1 and 2 in connection test of research group were significantly higher than those of control group (P<0.05). Attempt number and correct number in research group in PASAT test were significantly lower than in control group (P<0.05). Number of search errors in research group was higher than in control group, while number of search correct, search total score and digital sign score were significantly lower than in control group (P<0.05). Total number of words, color and color / word count in research group were lower than in control group in Stroop color word test, and the difference was statistically significant (P<0.05). WMS-III test results between two group had no significant difference(P>0.05). Conclusion: The neurocognitive function in early stage in patients with first-episode schizophrenia has been extensively damaged. |
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