| 董婧婧,涂济源,刘春红,瞿领航,付 伟,刘艳菊.三七粉的利尿作用研究[J].,2017,17(22):4223-4226 |
| 三七粉的利尿作用研究 |
| Study on the Diuretic Effect of Powder of Panax notoginseng (Burk.) F. H. Chen |
| 投稿时间：2017-03-05 修订日期：2017-03-23 |
| DOI：10.13241/j.cnki.pmb.2017.22.005 |
| 中文关键词: 三七粉 利尿作用 胃水负荷模型 |
| 英文关键词: Powder of Panax notoginseng (Burk.) F. H. Chen Diuretic effect |
| 基金项目:国家中医药管理局2015年中医药部门公共卫生专项资金（中药科技类）项目“中药炮制技术传承基地” |
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| 中文摘要: |
| 摘要 目的：研究三七粉对大鼠的利尿作用及相关机制。方法：建立大鼠胃水负荷模型，采用代谢笼法考察不同剂量三七粉对模型大鼠的利尿作用；测定Na+、K+、Cl-排出量，研究其相关机理。结果：三七粉高剂量组灌胃给药后，第2 h到第5 h能显著增加大鼠的排尿量，与空白组比较有显著性差异(P＜0.01，P＜0.05)，给药后第6 h以后基本无利尿作用。三七粉高剂量增加尿液Na+、Cl-排出(P＜0.01)，减少 K+排泄，抑制了肾小管对 Na+的重吸收和K+的排泄。三七粉高剂量能明显升高大鼠尿液pH值(P＜0.01)，其对pH值的影响效果与氢氯噻嗪、金钱草颗粒的影响效果相近。结论：三七粉具有明显利尿作用，能显著提高胃水负荷模型大鼠尿量，其机制可能与三七粉影响了肾小管对 Na+的重吸收和K+的排泄有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the diuretic effect of micronized powder of Panax notoginseng (Burk.) F. H. Chen on rats. Methods: The metabolic cage method and weighing method were used in this experiment; The indictor of urine excretion in 6 h was used to study the diuretic effect of powder of Panax notoginseng (Burk.) F. H. Chen in the water loaded rats; the output of Na +, K +, Cl- in urine were measured to elucidate the related mechanization. Results: Powder of Panax notoginseng (Burk.) F. H. Chen under high dose after administration of 2h to 5h can significantly increase the urine volume of rat compared with the blank control group (P＜0.01, P＜0.05), but no diuretic effect after administration of 6h. powder of Panax notoginseng (Burk.) F. H. Chen under high dose could increase the urine Na+, Cl- (P＜0.01) but reduce the K+ excretion, inhibitting the Na+ reabsorption and K+ excretion of renal tubule. It could significantly increase rat urine pH value (P＜0.01), the effect of pH value by which is similar with the effect of hydrochlorothiazide and the effect of Jinqiancao granules. Conclusion: For the first time, this study investigated the diuretic effect of powder of Panax notoginseng (Burk.) F. H. Chen, The relevant mechanism is that powder of Panax notoginseng (Burk.) F. H. Chen have an impact on inhibitting the Na+ reabsorption and K+ excretion of renal tubule. |
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