| 何 放,徐达圆,罗鹏飞,王光毅,夏照帆.新型抗菌凝胶敷料治疗深II度烧伤创面的疗效评价[J].,2017,17(21):4051-4054 |
| 新型抗菌凝胶敷料治疗深II度烧伤创面的疗效评价 |
| Evaluation of the Therapeutic Effect of Prontosan Wound Gel Combined with Sulfadiazine Silver on the Deep Second Degree Burn Wounds |
| 投稿时间：2017-03-03 修订日期：2017-03-25 |
| DOI：10.13241/j.cnki.pmb.2017.21.012 |
| 中文关键词: 烧伤 抗菌凝胶敷料 磺胺嘧啶银霜 伤口愈合 创面感染 |
| 英文关键词: Burns Prontosan wound gel Sulfadiazine silver Wound healing Wound infection |
| 基金项目:国家自然科学基金面上项目（81171806，81671911） |
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| 中文摘要: |
| 摘要 目的：评价新型抗菌凝胶敷料普朗特联合磺胺嘧啶银霜治疗深Ⅱ度烧伤创面的临床疗效和安全性。方法：采用前瞻性随机对照的方法将 2015年3月至2016年5月来我科初次就诊的深Ⅱ度烧伤患者74例分为两组：试验组38例采用新型抗菌凝胶敷料普朗特联合磺胺嘧啶银霜治疗，对照组36例采用磺胺嘧啶银霜治疗。两组均采用规定的标准化创面处理方式，其余治疗均按常规进行。分别统计和比较两组的创面愈合时间、愈合率、创面细菌培养阳性率、换药时的疼痛程度，同时定期监测患者在用药期间有无实验室指标异常及不良反应的发生。结果：试验组创面愈合时间(21.11 3.13)d，明显短于对照组(25.28 4.50)d(P<0.01)。治疗后7 d、14 d、21 d，试验组创面愈合率分别为(26.63 5.21)%、(63.32 5.32)%、(92.66 4.19)%，均显著高于对照组(P<0.05)。治疗后7 d、14 d，试验组分别有5例(13.16%)和1例(2.63%)创面细菌培养阳性，明显低于对照组的12例(33.33%)和8例(22.22%)(P<0.05)。治疗后7 d、14 d、21 d，试验组换药时的疼痛评分均明显低于对照组(P<0.05)。两组治疗期间实验室检查指标均无异常波动，均未见明显不良反应。结论：新型抗菌凝胶敷料普朗特联合磺胺嘧啶银霜治疗深Ⅱ度烧伤创面能缩短愈合时间，提高愈合率，减少创面感染发生，减轻患者痛苦。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the efficacy and safety of Prontosan wound gel combined with sulfadiazine silver on the deep second degree burn wounds. Methods: 74 patients with deep second degree burn who were treated for the first time from March 2015 to May 2016 were divided into two groups by using a prospective, randomized study: 38 cases in the experimental group were treated with Prontosan wound gel combined with sulfadiazine silver and 36 cases in the control group were given sulfadiazine silver alone. Both groups were treated with specified wound treatment standardly, the rest of the treatment measures as a routine treatment program. The healing time of burn wounds, recovering rate, bacterial culture positive rate, pain intensity were measured. The laboratory and clinical adverse reactions were regularly monitored during the treatment. Results: The healing time of experimental group was significantly shorter than that of the control group [(21.11 3.13)d vs (25.28 4.50)d](P<0.01). On the 7th, 14th and 21st after treatment, the recovering rates [(26.63 5.21)%, (63.32 5.32)%, (92.66 4.19)% ] of experimental group were higher than those of the control group (P<0.05). The positive rate of bacterial culture [5 cases (13.16%), 1 case (13.16%)] of experimental group were significantly lower than those[12 cases(33.33%), 8 cases(22.22%)] of the control group on the 7th, 14th day after treatment (P<0.05). The pain scores of experimental group were also significantly lower than those of the control group on the 7th, 14th day after treatment (P<0.05). There was no adverse reactions in the two groups during the treatment. Conclusion: Prontosan wound gel combined with sulfadiazine silver could shorten the healing time, increase the healing rate, reduce the incidence of wound infections and alleviatethe pain in treating the deep second degree burn wounds. |
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