| 唐春梅,赵会杰,许 刚,阎 妍,宋其义.牙周组织再生术联合口腔正畸对牙周炎患者血清炎症因子水平的影响及其疗效探究[J].,2017,17(20):3965-3968 |
| 牙周组织再生术联合口腔正畸对牙周炎患者血清炎症因子水平的影响及其疗效探究 |
| Clinical Effect of Periodontal Regeneration Combined with Oral Orthodontic on Periodontitis Patients and Levels of Serum IL-6, IL-8 and TNF-α |
| 投稿时间：2016-12-02 修订日期：2016-12-27 |
| DOI：10.13241/j.cnki.pmb.2017.20.039 |
| 中文关键词: 牙周组织再生术 口腔正畸 牙周炎 疗效 |
| 英文关键词: Periodontal tissue regeneration Orthodontics Periodontitis Effect |
| 基金项目:辽宁省自然科学基金项目(20042062) |
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| 中文摘要: |
| 摘要 目的：研究牙周组织再生术联合口腔正畸对牙周炎患者血清白介素-6(IL-6)、白介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)水平的影响及其疗效。方法：选取2014年11月至2015年10月本院收治的78例牙周炎患者，按照入院顺序分为观察组和对照组，39例每组。对照组采取单纯的牙周组织再生术，观察组在此基础上联合口腔正畸进行治疗。治疗后，评价两组患者治疗的临床疗效，比较两组患者治疗前和治疗3个月后血清IL-6、IL-8、TNF-α水平、牙龈指数(GI)、龈沟出血指数(SBI)、牙菌斑指数(PLI)、牙周探诊深度(PD)、临床附着丧失(AL)的变化。结果：治疗后，观察组总的有效率显著高于对照组(P<0.05)，血清IL-6、IL-8、TNF-α水平、GI、SBI、PLI、PD、AL均显著低于对照组(P<0.05)。结论：牙周组织再生术联合口腔正畸治疗能有效降低牙周炎患者血清IL-6、IL-8、及TNF-α水平，提高其临床疗效。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical effect of periodontal regeneration combined with oral orthodontic on the periodontitis patients and its influence on the levels of serum interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α). Methods: From November 2014 to October 2015, 78 patients with periodontitis were admitted in our hospital and divided into the observation group and the control group according to the order of admission, 39 patients in each group. The control group was given simple periodontal tissue regeneration, while the observation group was given orthodontic for treatment on the basis of control group. The serum IL-6, IL-8, TNF-α levels, gingival index (GI), sulcus bleeding index (SBI), plaque(PLI), periodontal probing depth (PD), clinical attachment loss (AL) were measured before and after treatment for 3 months between the two groups, and the clinical efficacy of the two groups were evaluated. Results: After treatment, the total effective rate in the observation group was significantly higher than of the control group(P<0.05). The levels of serum IL-6, IL-8 and TNF-α in the observation group were significantly lower than those in the control group (P <0.05). The GI, SBI, PLI, PD and AL in the observation group were significantly lower than those of the control group (P<0.05). Conclusion: Periodontal tissue regeneration combined with oral orthodontic treatment could effectively reduce the levels of serum IL-6, IL-8 and TNF-α of patients with periodontitis, and enhance the clinical effect. |
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