| 孟根托娅,陈凤英,牛君义,李香枝,谢秀峰,刘丽君.围术期阿托伐他汀强化治疗对急性ST段抬高型心肌梗死患者Lp-PLA2与炎症因子的影响[J].,2017,17(20):3880-3882 |
| 围术期阿托伐他汀强化治疗对急性ST段抬高型心肌梗死患者Lp-PLA2与炎症因子的影响 |
| Effects of Loading Dose of Atorvastatin on Phospholipases A2 and Inflammatory Cytokines in Acute Myocardial Infarction Patients Undergoing Emergency Percutaneous Coronary Intervention |
| 投稿时间：2016-10-27 修订日期：2016-11-21 |
| DOI：10.13241/j.cnki.pmb.2017.20.018 |
| 中文关键词: 急性ST段抬高型心肌梗死 经皮冠状动脉介入治疗术 阿托伐他汀 脂蛋白相关磷脂酶A2 炎症因子 |
| 英文关键词: Acute Myocardial Infarction Percutaneous Coronary Intervention Atorvastatin Phospholipases A2 Inflammatory Cytokines |
| 基金项目:内蒙古医科大学支持基金项目（1505061） |
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| 中文摘要: |
| 摘要 目的：探讨阿托伐他汀强化治疗对急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗术后脂蛋白相关磷脂酶A2及炎症因子的影响。方法：选取98例行急诊经皮冠状动脉介入治疗术的急性ST段抬高型心肌梗死患者作为研究对象，随机分为A组和B组，各49例。A组患者术前顿服阿托伐他汀40 mg，术后继续口服阿托伐他汀40 mg/24 h；B组患者术前顿服阿托伐他汀20 mg，术后继续口服阿托伐他汀20 mg/24 h。比较两组患者在治疗前后的脂蛋白相关磷脂酶A2（Lp-PLA2）、白细胞介素（IL）-6/肿瘤坏死因子（TNF）-α 、丙氨酸转氨酶（ALT）及天冬氨酸转氨酶（AST）等炎症因子的水平。结果：治疗前两组患者的Lp-PLA2、IL-6、TNF-α、ALT及AST等因子水平的差异均无统计学意义（P>0.05）；治疗后，两组患者的Lp-PLA2、IL-6、TNF-α、ALT及AST等因子水平均高于治疗前（P<0.05），且A组患者的Lp-PLA2、IL-6及TNF-α因子水平明显低于B组（P<0.05），两组患者ALT、AST的水平无统计学差异（P>0.05）。结论：围术期阿托伐他汀强化治疗能显著降低急性ST段抬高型心肌梗死患者的炎症因子水平与稳定斑块，疗效显著。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effects of loading dose of atorvastatin on phospholipases A2 and inflammatory cytokines in acute myocardial infarction (AMI) patients undergoing emergency percutaneous coronary intervention. Methods: A total of 98 patients with AMI who underwent emergency percutaneous coronary intervention were selected and divided into group A and group B randomly. Each group had 49 cases. Patients in group A took atorvastatin 40 mg at a draught before operation and 40mg/24h after operation. While patients in group B only took atorvastatin 20mg at a draught before operation and 20 mg/24h after operation. To compare the levels of phospholipases A2 (Lp-PLA2), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), alanine transaminase (ALT) and aspartate transaminase (AST) of the two groups before and after the treatment. Results: Before the treatment, there were no significant differences in Lp-PLA2, IL-6, TNF-α, ALT and AST levels between two groups (P＞0.05). After the treatment, the levels of Lp-PLA2, IL-6, TNF-α, ALT and AST were all higher than before treatment (P<0.05). And, the levels of Lp-PLA2, IL-6, TNF-α in the group A were lower than in the group B(P<0.05), but there were no significant differences in ALT and AST after PCI between two groups (P＞0.05). Conclusion: The high loading dose of atorvastatin in AMI patients who underwent emergency PCI can reduce the inflammatory cytokines levels, and decrease the inflammation. It had distinct curative effect and high safety and it can stabilize the plaques in acute stage. |
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