| 郭建华,高 彬,王 琼,张麦叶,张娜娜,贾爱华,王晓东,鱼馨文,姬秋和.垂体功能减退症患者和低促性腺激素性性腺功能减退症患者糖脂代谢的研究[J].,2017,17(20):3876-3879 |
| 垂体功能减退症患者和低促性腺激素性性腺功能减退症患者糖脂代谢的研究 |
| A Comparative Study on the Characteristics of Glucose and Lipid Metabolism in Young Men with panhypopituitarism(Hypo-Pit) and with Hypogonadotropic Hypogonadism (HH) |
| 投稿时间：2017-01-09 修订日期：2017-01-30 |
| DOI：10.13241/j.cnki.pmb.2017.20.017 |
| 中文关键词: 垂体功能减退症 性腺功能减退症 胰岛素抵抗 糖脂代谢 |
| 英文关键词: Hypopituitarism Hypogonadism Insulin Resistance Glucose and lipid metabolism |
| 基金项目:国家自然科学基金项目（81300696）；陕西省自然科学基础研究项目（2015JM8471）；陕西省科技统筹创新工程计划项目课题（2013KTZB03-02-01）；西京医院学科助推计划转化医学课题（XJZT13204） |
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| 中文摘要: |
| 摘要 目的：比较垂体功能减退症患者（Hypopituitarism, Hypo-Pit）与低促性腺激素性性腺功能减退症(Hypogonadotropic hypogonadism, HH)的糖脂代谢状况。方法：收集从2013年6月至2016年9月在西京医院内分泌代谢科确诊的Hypo-Pit及HH男性患者的临床资料，分别有32例Hypo-Pit患者和43例HH患者纳入本研究，对照组为22例年龄、体质指数（BMI）与研究组相匹配，且无糖尿病等慢性疾病家族史的男性。采集空腹静脉血后测定血脂水平，行3h口服葡萄糖耐量试验（OGTT），测定血糖及胰岛素水平，计算葡萄糖、胰岛素曲线下面积、胰岛素抵抗指数等。3组间计量资料组间的比较应用LSD方差分析检验，非正态分布的数据经自然对数转换(ln)后进行分析。结果：各组间年龄、BMI均无统计学差异（P>0.05）；与正常对照组相比，Hypo-Pit患者及HH患者的高密度脂蛋白水平下降（均P<0.05），甘油三酯水平升高（P<0.05）；与HH患者相比，Hypo-Pit患者的胆固醇、甘油三酯、低密度脂蛋白升高（P<0.05）；与正常对照组相比，HH患者的稳态模型胰岛素抵抗指数及胰岛素敏感指数升高（P<0.05）；与对照组比较，Hypo-Pit患者及HH患者OGTT 3h血糖水平升高，差异有统计学意义（均P<0.05）；HH患者空腹、2h、3h血清胰岛素水平均明显升高，差异有统计学意义（均P<0.05）；与HH组相比，Hypo-pit患者的HOMA-IR水平降低（P<0.05）。结论：Hypo-Pit患者存在糖脂代谢紊乱，且脂代谢紊乱较HH患者更差，而HH患者胰岛素抵抗水平高于Hypo-Pit患者。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the characteristics of glucose and lipid metabolism in young men with panhypopituitarism(Hypo-Pit) and compare with hypogonadotropic hypogonadism (HH). Methods: We studied 43 untreated men with HH and 32 men with Hypo-Pit. 22 healthy young men of similar age and body mass index (BMI) were recruited in the control group from June 2013 to September 2016. Serum lipids levels were measured in fasting blood samples. Plasma glucose and insulin levels were taken during oral glucose tolerance test (OGTT) test. Areas under the curves of glucose (AUCG) and insulin (AUCI), homeostasis model assessment of insulin resistance (HOMA-IR), and other metabolic parameters were calculated respectively. Data among three groups were analyzed by LSD analysis of variance. Non-normal distribution data was analyzed after natural logarithmic transformation. Results: No significant differences were showed in age and BMI（both P>0.05). Compared with the control group, triglyceride (TG) was significantly higher (both P<0.05), high density lipoprotein-cholesterol (HDL-c) in blood and systolic blood pressure (SBP) were lower (both P<0.05) in Hypo-Pit men and HH group; Compared with the HH patients, total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-c) in blood were higher (all P<0.05) in Hypo-Pit men. Compared with the control group, homeostasis model assessment-insulin resistance (HOMA-IR), areas under the curves of insulin (AUCI) and homeostasis model assessment pancreatic β-cell function (HOMA-β) were higher (both P<0.05) in the HH group, 3 h postprandial plasma glucose (3hPG) was higher (both P<0.05) in Hypo-Pit men and HH men. The insulin levels at 0 h, 2 h and 3 h all significantly increased in the HH group (all P<0.05). Conclusion: Panhypopituitarism patients are more likely to develop glucose and lipid metabolism disorder compared with healthy men at the same age. But compared with the Hypo-Pit patients, HOMA-IR is higher in HH men. |
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