| 杨 涛,张 韬,陈华茜,张 任,赵 黎,李正东.百令片联合坎地沙坦对糖尿病肾病患者的临床效果分析[J].,2017,17(19):3722-3725 |
| 百令片联合坎地沙坦对糖尿病肾病患者的临床效果分析 |
| The Influence of Bailing Film Combined Candesartan on Serum Cys - C and ?茁2-MG Level with Diabetic Nephropathy |
| 投稿时间：2016-12-08 修订日期：2016-12-29 |
| DOI：10.13241/j.cnki.pmb.2017.19.031 |
| 中文关键词: 糖尿病肾病 百令片 坎地沙坦 胱抑素C β2微球蛋白 |
| 英文关键词: Diabetic nephropathy Bailing film Candesartan Cystatin-c β2microglobulin |
| 基金项目:湖北省自然科学基金项目(99142) |
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| 中文摘要: |
| 摘要 目的：分析百令片联合坎地沙坦对糖尿病肾病患者的临床治疗效果。方法：选择我院2015年6月~2016年6月收治的98例糖尿病肾病作为研究对象，参照抽签法随机分为对照组与观察组，每组各49例。对照组予以坎地沙坦治疗，观察组基于对照组使用百令片治疗，比较两组治疗前后血清胱抑素(Cys-C)、β2微球蛋白(β2-MG)、尿素氮(BUN)、肌酐(Cr)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、血糖、血压水平和不良反应的发生情况。结果：治疗后，两组血清Cys-C、β2-MG、BUN、Cr、IL-6、CRP、TNF-α、血糖和血压水平均较治疗前显著降低，且观察组血清Cys-C、β2-MG、BUN、Cr、IL-6、CRP、TNF-α和血压水平显著低于对照组，差异均具有统计学意义(P<0.05)。结论：百令片联合坎地沙坦治疗可更有效改善糖尿病肾病患者的肾功能、血压和血糖水平，抑制其炎症反应，且安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinical effect of Bailing film combined candesartan on the diabetic nephropathy. Methods: 98 cases of patients with diabetic nephropathy in our hospital from June 2015 to June 2015 were selected and divided into the control group and the observation group according to the method of drawing lots with 49 cases in each group. The control group was treated with candesartan, while the observation group was treated by Bailing tablets based on the control group. The blood index, blood pressure be- fore and after treatment and the incidence of adverse reactions between two groups were compared. Results: After treatment, the serum levels of Cystatin-c(Cys-C), β2-microglobulin (β2-MG), BUN, Cr, IL-6, CRP, TNF-α, blood glucose and blood pressure of both groups were lower than those before treatment, and the serum levels of Cys-C, β2-MG, BUN, Cr, IL-6, CRP, TNF-α, blood glucose and blood pressure of observation group were significantly lower than those of the control group(P<0.05). Conclusion: Bailing film combined with candesartan could more effectively improve the renal function, blood pressure and blood glucose levels, inhibit the inflammatory re- sponse with high safety in the treatment of diabetic nephropathy. |
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