| 李小丽,刘鲁沂,田行瀚,李梅凤,于清霞.连续性血浆滤过吸附对严重感染合并MODS患者炎症因子水平的影响[J].,2017,17(19):3700-3702 |
| 连续性血浆滤过吸附对严重感染合并MODS患者炎症因子水平的影响 |
| Effect of Continuous Plasma Filtration Adsorption on the Levels of Inflammatory Factors in Patients with Severe Infection and MODS |
| 投稿时间：2016-10-17 修订日期：2016-10-30 |
| DOI：10.13241/j.cnki.pmb.2017.19.025 |
| 中文关键词: 连续性血浆滤过吸附 感染 多脏器功能障碍综合征 生命体征 APACHEⅡ评分 炎症因子 |
| 英文关键词: Continuous plasma filtration adsorption Infection Multiple organ dysfunction syndrome Vital signs APACHE II score Inflammatory factors |
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| 中文摘要: |
| 摘要 目的：探讨连续性血浆滤过吸附对严重感染合并多脏器功能障碍综合征（MODS）患者炎症因子水平的影响。方法：研究对象选取我院2013年3月-2016年3月收治严重感染合并MODS患者共160例，以随机数字表法分为对照组（80例）和观察组（80例），患者均先给予高容量血液滤过（HVHF）治疗，观察组加用连续性血浆滤过吸附辅助治疗，比较两组患者治疗前后平均动脉压（MAP）、心率（HR）、血氧饱和度（SpO2）、碳酸氢根（HCO3-）、肌酐（Scr）、总胆红素（TBiL）、急性生理与慢性健康II（APACHEⅡ）评分、肿瘤坏死因子α（TNF-α）、超敏C反应蛋白（hs-CRP）及白介素6（IL-6）水平。结果：两组治疗后MAP、Scr、TBiL、TNF-α、IL-6、hs-CRP及APACHEⅡ评分均有所降低，而HR、SpO2、HCO3-水平均上升，且观察组以上各指标改善更明显，差异均有统计学意义（P<0.05）。结论：连续性血浆滤过吸附辅助治疗严重感染合并MODS可有效稳定生命体征，改善生化指标，延缓病情进展，并有助于降低机体炎症反应水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of continuous plasma filtration adsorption on the level of inflammatory factors in patients with severe infection and multiple organ dysfunction syndrome(MODS). Methods: 160 patients with severe infection and MODS were chosen in our hospital from March 2013 to March 2016 and divided into both groups including control group (80 cases) and obser- vation group (80 cases) by the random number table method, Patients were all treated with high volume hemofiltration (HVHF), the ob- servation group was treated with continuous plasma filtration and adsorption.Compared the mean arterial pressure (MAP), heart rate (HR), oxygen saturation (SpO2),bicarbonate (HCO3-), creatinine (Scr), total bilirubin (TBiL), acute physiology and chronic health evalua- tion II (APACHE II), tumor necrosis factor-α (TNF-α), high sensitivity C C-reactive protein (hs-CRP) and interleukin 6 (IL-6) level of two groups before and after treatment. Results: After treatment, MAP, Scr, TBiL, TNF-α, IL-6, hs-CRP and APACHE score were de- creased in two groups, while HR, SpO2 and HCO3- levels were increased, and the all indexes of observation group improved obviously, the differences were statistically significant (P<0.05). Conclusion: Continuous plasma filtration adsorption in the treatment of patients with severe infection and MODS can efficiently stable vital signs, improve the biochemical parameters,delay the disease progression and be helpful to reduce the level of inflammation in the body. |
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