| 刘志为,李 超,刘 庆,胡茂飞,闻 巍,韩 炜.腹腔镜胃癌根治术治疗胃癌的疗效及对患者血清TNF-α与IL-1β水平的影响[J].,2017,17(18):3502-3505 |
| 腹腔镜胃癌根治术治疗胃癌的疗效及对患者血清TNF-α与IL-1β水平的影响 |
| Clinical Effect of Laparoscopic Radical Gastrectomy on Serum Levels of TNF-α and IL-1β in Patients with Gastric Cancer |
| 投稿时间：2016-11-29 修订日期：2016-12-22 |
| DOI：10.13241/j.cnki.pmb.2017.18.023 |
| 中文关键词: 腹腔镜胃癌根治术 胃癌 肿瘤坏死因子-α 白介素-1β |
| 英文关键词: Laparoscopic radical gastrectomy Gastric cancer Tumor necrosis factor-α Interleukin-1β |
| 基金项目:海南省自然科学基金项目（12KH0846） |
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| 中文摘要: |
| 摘要 目的：研究腹腔镜胃癌根治术对胃癌患者的临床疗效及其对患者血清肿瘤坏死因子-α(TNF-α)与白介素-1β(IL-1β)的影响。方法：选取2014年8月至2015年7月本院收治的84例胃癌患者，随机分为观察组和对照组，每组42例。对照组采用传统开腹手术治疗，观察组采取腹腔镜胃癌根治术治疗。比较两组患者的手术指标，手术前后TNF-α、IL-1β细胞因子水平，术后并发症的发生情况。结果：两组患者的淋巴结清扫数量比较无显著性差异(P>0.05)，观察组手术时间长于对照组，但观察组的术中出血量明显少于对照组(P>0.05)，首次排气时间、首次下床活动时间、首次进食时间、术后住院时间明显短于对照组(P<0.05)。术后1天，观察组的TNF-α与IL-1β水平显著低于对照组(P<0.05)。观察组的切口感染、肺部感染发生率显著低于对照组(P<0.05)，两组患者的吻合口瘘、吻合口出血、术后胃瘫并发症发生率比较无显著性差异(P>0.05)。结论：腹腔镜胃癌根治术治疗胃癌具有切口小、手术时间短、出血量少、恢复快、安全性高等优势，临床疗效良好，且能降低患者围术期血清TNF-α、IL-1β水平。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical effect of laparoscopic radical gastrectomy on the serum TNF-α, IL-1β levels of patients with gastric cancer. Methods: From August 2014 to July 2015, 84 patients with gastric cancer admitted in our hospital were divided into the observation group and control group according to the order of admission. The control group was given the traditional open surgery, the observation group was treated by laparoscopic radical gastrectomy. The surgical index, serum levels of TNF-α, IL-1β before and after operation and the incidence of postoperative complications were compared between the two groups. Results: There was no significant difference in the number of lymph nodes dissection between two groups (P>0.05). The operation time of observation group was longer than that of the control group, but the intraoperative blood loss was significantly less than that of the control group (P>0.05), the time of first out of bed, time of first meal and time of hospitalization were significantly shorter than those of the control group (P <0.05). The serum levels of TNF-α and IL-1β in the observation group were significantly lower than those in the control group (P<0.05). The incisional infection rate and pulmonary infection rate in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in the incidence rates of anastomotic leakage, anastomotic bleeding and postoperative complications of gastroparesis between two groups(P>0.05). Conclusion: Laparoscopic radical gastrectomy had advantages of smaller incision, shorter operation time, less blood loss, quicker recovery and higher safety than general surgery in the treatment of gastric cancer, and it could significantly reduce the serum TNF-α, IL-1β levels. |
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