| 魏娟娟,张海平,贺文艳,高晓丽,白雪梅,杜 波.感染耐亚胺培南鲍曼不动杆菌临床分布情况及耐药性分析[J].,2017,17(16):3148-3151 |
| 感染耐亚胺培南鲍曼不动杆菌临床分布情况及耐药性分析 |
| Clinical Distribution and Resistance of Imipenem-resistant Acinetobacter Baumannii of Patients |
| 投稿时间：2016-08-23 修订日期：2016-09-25 |
| DOI：10.13241/j.cnki.pmb.2017.16.038 |
| 中文关键词: 鲍曼不动杆菌 亚胺培南 临床分布 耐药性 |
| 英文关键词: Acinetobacer baumannii Imipenem Clinical distribution Drug resistance |
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| 中文摘要: |
| 摘要 目的：探讨感染耐亚胺培南（IPM）鲍曼不动杆菌临床分布情况及耐药性。方法：回顾性分析2013~2015年榆林市中医院患者感染鲍曼不动杆菌的临床分布，并对耐亚胺培南鲍曼不动杆菌进行培养、鉴定及药敏试验，分析其耐药情况。结果：2013~2015年我院共分离培养出鲍曼不动杆菌185株，其中IPM耐药99株（53.51 %），IPM敏感86株（46.49 %）。绝大部分菌株分离自痰液标本（138株，74.59 %），其次是血液标本（14株，7.57 %）与尿液标本（12株，6.49 %）；来自ICU送检标本菌株数量最多（84株，45.41 %），其次是呼吸内科标本（53株，28.65 %）与神经内科标本（30株，16.22 %）。不同标本类型及科室中IPM耐药及IPM敏感鲍曼不动杆菌占比无显著差异（P>0.05）。IPM耐药鲍曼不动杆菌对抗菌药物耐药性均较高，其中以头孢哌酮/舒巴坦（CSL）敏感性最高（50.51 %）；IPM敏感鲍曼不动杆菌对部分抗菌药物耐药性尚可，其中以IPM敏感性最高（93.02 %）。结论：耐亚胺培南鲍曼不动杆菌临床分布广泛，多重耐药性严重甚至出现泛耐药，应当对患者进行药敏试验，以药敏结果选择合适的抗菌药物进行使用。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical distribution and resistance of imipenem (IPM)-resistant Acinetobacter baumannii of patients. Methods: The clinical distribution of IPM-resistant Acinetobacer baumannii of patients in Traditional Chinese Medicine Hospital of Yulin from 2013 to 2015 was retrospectively analyzed. Results: 185 IPM-resistant Acinetobacer baumannii were isolated cultured, and there were 99 IPM- resistance (53.51 %) and 86 IPM-sensitivity (46.49 %). Most of the strains were isolated from sputum specimen (138, 74.59 %), then the blood specimen (14, 7.57 %) and urine specimen (12, 6.49 %). Most of the strains were sent from ICU (84, 45.41 %), then the respiratory internal department (53, 28.65 %) and neurology department (30, 16.22 %). There were no big difference of the amounts of IPM-resistant and IPM-sensitivity between different specimens and departments (P>0.05). IPM-resistant Acinetobacer baumannii had higher resistance of antibacterial drugs, which had the highest sensitivity of cefoperazone/sulbactam (CSL) (50.51 %). IPM-sensitivity Acinetobacer baumannii had better resistance of antibacterial drugs, which had the highest sensitivity of IPM (93.02 %). Conclusion: IPM-resistant Acinetobacer baumannii widely distribute, which has severe drug resistance or pan-drug resistance, so the clinical doctors should carry on drug resistance test to choose the property antibacterial drugs. |
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