| 王胜强,李吉刚,赵爱荣,张 俭,胡建强.重组脑钠肽对急性失代偿性心力衰竭患者炎症因子及肾素系统的影响[J].,2017,17(16):3072-3075 |
| 重组脑钠肽对急性失代偿性心力衰竭患者炎症因子及肾素系统的影响 |
| Effects of Recombinant Brain Natriuretic Peptide on Inflammatory Factors and Renin System in Patients with Acute Decompensated Heart Failure |
| 投稿时间：2016-11-15 修订日期：2016-11-30 |
| DOI：10.13241/j.cnki.pmb.2017.16.018 |
| 中文关键词: 急性失代偿性心力衰竭 重组脑钠肽 炎症因子 肾素系统 |
| 英文关键词: Acute decompensated heart failure Recombinant brain natriuretic peptide Inflammatory factor Renin system |
| 基金项目:山东省自然科学基金项目(2002BB1CJA1) |
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| 中文摘要: |
| 摘要 目的：探讨重组脑钠肽对急性失代偿性心力衰竭患者炎症因子及肾素系统的影响。方法：选择2014年7月~2016年7月于我院就诊的急性失代偿性心力衰竭患者160例，80例对照组行硝普钠治疗，80例实验组行重组脑钠肽治疗，观察两组治疗前后肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、脑钠肽（BNP），醛固酮、血管紧张素Ⅱ、血浆肾素活性，血流动力学变化及心功能情况。结果：治疗前，实验组TNF-α、hs-CRP、IL-6、BNP低于对照组，差异有统计学意义（P<0.05）。实验组醛固酮、血管紧张素Ⅱ、血浆肾素活性低于对照组，差异有统计学意义（P<0.05）。实验组血流动力学低于对照组（P<0.05）。实验组心功能较对照组改善更明显（P<0.05）；实验组副反应少于对照组（P<0.05）。结论：急性失代偿性心力衰竭患者应用重组脑钠肽治疗可降低患者炎症因子，改善肾素系统。 |
| 英文摘要: |
| ABSTRACT Objective: To research the effects of recombinant brain natriuretic peptide on inflammatory factors and renin system in patients with acute decompensated heart failure. Methods: 160 patients with acute decompensated heart failure who were treated in our hospital from July 2014 to July 2016 were selected and randomly divided into two groups, with 80 cases in each group. The patients in the control group were treated with sodium nitroprusside, while the patients in the experimental group were treated with recombinant brain natriuretic peptide. Then the serum levels of tumor necrosis factor alpha (TNF-α), hypersensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6), brain natriuretic peptide (BNP), aldosterone, aldosterone Ⅱ, plasma renin activity, hemodynamics and heart functions of patients between the two groups were observed and compared before and after the treatment. Results: After treatment, the serum levels of TNF-α, hs-CRP, IL-6 and BNP of the experimental group were lower than those of the control group, and the differences were statistically significant (P<0.05); After treatment, the levels of the aldosterone, aldosterone Ⅱ and plasma renin activity of the experimental group were lower than those of the control group, and the differences were statistically significant (P<0.05); After treatment, the hemodynamics of the experimental group was lower than that of the control group, and the difference was statistically significant (P<0.05). The improvement of heart function of the experimental group was more obvious than that of the control group (P<0.05). The incidence of complications in the experimental group was lower than that of the control group (P<0.05). Conclusion: Recombinant brain natriuretic peptide has better clinical efficacy on the treatment of the acute decompensated heart failure, which can reduce the serum levels of the inflammatory factors, and improve the renin-angiotensin-aldosterone system. |
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