| 武树朋,王 静,李 芳,朱广婷,聂深钰.强直性脊柱炎患者血清MMP-3和IL-15水平的表达及临床意义[J].,2017,17(14):2729-2731 |
| 强直性脊柱炎患者血清MMP-3和IL-15水平的表达及临床意义 |
| Expression and Clinical Significance of MMP-3 and IL-15 of Ankylosing Spondylitis |
| 投稿时间：2016-11-12 修订日期：2016-11-30 |
| DOI：10.13241/j.cnki.pmb.2017.14.032 |
| 中文关键词: 强直性脊柱炎 血清学指标 MMP-3 IL-15 |
| 英文关键词: Ankylosing spondylitis Serological indicator MMP-3 IL-15 |
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| 中文摘要: |
| 摘要 目的：研究强直性脊柱炎（AS）患者血清基质金属蛋白酶-3(MMP-3)和白细胞介素-15(IL-15)水平的表达及临床意义。方法：选取从2015年1月至2016年9月在我院就诊的AS患者50例。根据Bath强直性脊柱炎疾病活动性指数（BASDAI）将患者分为A组（指数≥6）28例，B组（指数＜6）22例。此外，按照Bath强直性脊柱炎功能指数（BASFI）将患者分为Ⅰ组（指数≥6）29例，Ⅱ组（指数＜6）21例。另取同期健康体检者30例记为对照组。分别对比A、B组以及Ⅰ、Ⅱ组与对照组的血清MMP-3和IL-15水平，并作相关性分析。结果：A组MMP-3、IL-15水平均显著高于B组及对照组，而B组又显著高于对照组，差异均有统计学意义（均P＜0.05）。Ⅰ组MMP-3、IL-15水平均显著高于Ⅱ组与对照组，而Ⅱ组又显著高于对照组，差异均有统计学意义（均P＜0.05）。经相关性分析可得，AS患者BASDAI、BASFI与MMP-3、IL-15均呈显著正相关（P＜0.05）。结论：血清MMP-3和IL-15在AS患者中高表达，且在疾病的发生发展中具有重要作用，可作为临床判断AS患者病情严重程度的血清学指标。 |
| 英文摘要: |
| ABSTRACT Objective: To study the expression and clinical significance of serum levels of matrix metalloproteinase-3 (MM-3) and interleukin-15 (IL-15) of patients with ankylosing spondylitis (AS). Methods: Selected 50 cases of AS from January 2015 to September 2016 in our hospital, according to the Bath ankylosing spondylitis disease activity index (BASDAI) patients can be divided into group A (index≥6) 28 cases, group B (index<6) 22 cases. In addition, according to the Bath ankylosing spondylitis functional index (BASFI) divided the patients into Ⅰ group (index≥6) 29 cases, Ⅱ group (index<6) 21 cases according to the patients. Selected another 30 healthy cases as control group. Compared and did correlation analysis of serum MMP-3 and IL-15 levels of groups. Results: The group A of MMP-3, IL-15 levels were significantly higher than that of B group and the control group, and group B was significantly higher than the control group, which were statistically significant differences (all P<0.05). Through correlation analysis, AS patients with BASDAI,BASFI and IL-15, MMP-3 were significantly positively correlated (P<0.05). Conclusion: High expression of serum MMP-3 and IL-15 in AS patients, and has an important role in the occurrence and development of the disease, can be used as a serological indicator of the severity of AS in patients with clinical judgment. |
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