| 常 宁,韩志萍,张信信,张 勇,张 艰.晚期NSCLC患者血液EGFR基因检测研究进展[J].,2017,17(13):2594-2597 |
| 晚期NSCLC患者血液EGFR基因检测研究进展 |
| The Detection of EGFR Mutation Status in Blood in Advanced Non-small Cell Lung Cancer |
| 投稿时间：2016-11-19 修订日期：2016-12-16 |
| DOI：10.13241/j.cnki.pmb.2017.13.050 |
| 中文关键词: 非小细胞肺癌 表皮生长因子受体 血液 基因突变 |
| 英文关键词: NSCLC EGFR Blood Mutation |
| 基金项目:国家自然科学基金项目（81272518）；北京医学奖励基金会专项科研基金项目（273） |
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| 中文摘要: |
| 摘要：随着表皮生长因子受体酪氨酸酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitor, EGFR-TKI)在非小细胞肺癌（Non-Small Cell Lung Cancer，NSCLC）治疗中的应用，患者的生活质量及生存期均有很大程度的提高，但是，组织表皮生长因子受体（epidermal growth factor receptor，EGFR）检测结果为能否接受EGFR-TKI治疗的先决条件，而晚期肺癌患者却因组织量少、质量不佳、组织异质性无法进行检测，血液EGFR检测便应运而生，本研究将综述晚期非小细胞肺癌（Non-Small Cell Lung Cancer，NSCLC）患者血液EGFR基因检测研究。方法：检索Pub-med、SCI、Medline及中国生物文献数据库中晚期非小细胞肺癌患者血液EGFR基因检测的相关研究。结果：对于晚期NSCLC患者，血液EGFR基因检测有较高的敏感度与特异度，并且能够较好的预测患者对EGFR-TKI的疗效以及进行耐药监测。结论：当组织获取困难及质量不佳时，血液可替代组织行EGFR基因检测。 |
| 英文摘要: |
| ABSTRACT: With the application of EGFR-TKI in treatment for NSCLC patients, Survival time and quality of patients improved greatly. But the results of EGFR testing is the necessary condition for treatment of EGFR-TKI. But tumor tissues may often be of insufficient quality or quantity for EGFR mutation testing in NSCLC patients. Meanwhile the results may be bias owing to heterogeneity. Therefore liquid biopsies will be imperative. This study aims to review the researches of EGFR testing in blood for the different results. Methods: We searched Pubmed, SCI and CBM for the literatures about EGFR mutation testing in blood. Risk ratio(RR) and hazard ratio(HR) were used as measures for clinical response to EGFR-TKIs and PFS for the mutant and wild patients. Results: The testing of EGFR seems to have higher sensitivity and specificity, meanwhile it can predict the efficacy of EGFR-TKI and monitor the drug resistance. Con- clusion: Blood can became an effective substitution for EGFR mutation testing for advanced NSCLC when it often be of insufficient quality or quantity of tumor tissue. |
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