| 陈 英,钟 波,付 洪,张 敏,周 琦.血清TNF-α、IL-6，8水平与复发性阿弗他溃疡患者免疫功能的关系研究[J].,2017,17(13):2528-2530 |
| 血清TNF-α、IL-6，8水平与复发性阿弗他溃疡患者免疫功能的关系研究 |
| Correlation of TNF-α, IL-6, 8 and Immune Function in Patients with Recurrent Aphthous Ulcers |
| 投稿时间：2016-09-13 修订日期：2016-10-08 |
| DOI：10.13241/j.cnki.pmb.2017.13.033 |
| 中文关键词: 复发性阿弗他溃疡 TNF-α IL-6 IL-8 免疫功能 |
| 英文关键词: Recurrent aphthous ulcer TNF-α IL-6 IL-8 Immune function |
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| 中文摘要: |
| 摘要 目的：探讨血清肿瘤坏死因子a (TNF-α)、白介素-6（IL-6）、白介素-8（IL-8）水平与复发性阿弗他溃疡（RAU）患者免疫功能的关系。方法：收集我院于2015年6月~2016年6月间收治的82例RAU患者作为观察组，另取80例健康体检人员作为对照组，比较两组血清TNF-α、IL-6,8、CD3+、CD4+、CD8+、CD4+/CD8+水平，并分析各指标的相关性。结果：观察组血清TNF-α、IL-6、IL-8、CD8+水平均高于对照组，差异均有统计学意义（P<0.05）。观察组CD4+、CD4+/CD8+水平低于对照组，差异均有统计学意义（P<0.05）；两组CD3+水平比较，差异无统计学意义（P>0.05）。血清TNF-α、IL-6,8水平与CD3+、CD4+、CD8+、CD4+/CD8+均呈负相关（P<0.05）。结论：RAU疾病的发生与机体免疫功能障碍有关，检测患者TNF-α、IL-6,8水平可反映出患者免疫功能水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-6 (IL-8) and immune function in patients with recurrent aphthous ulcers (RAU). Methods: 82 cases of patients with RAU in our hospital from June 2015-June 2016 were selected as the observation group；80 cases of healthy people were selected as the control group. The levels of serum TNF-α, IL-6, 8, CD3, CD4+ and CD8+, CD4/CD8 and their correlation were compared and analyzed. Results: The levels of serum TNF-α, IL-6, IL-8 and CD8+ were higher than the control group, the difference was statistically significant (P<0.05). The levels of CD4+,CD4+/CD8+ in observation group were lower than that of the control group, the difference was statistically significant (P<0.05); The levels of CD3+ in two groups had no statistically difference (P>0.05). Serum TNF-α, IL-6, 8 levels were negatively correlated with CD3+, CD4+, CD8+, CD4+/CD8+ (P<0.05). Conclusion: The incidence of RAU is related to immune dysfunction, detecting the levels of serum TNF-α, IL-6, 8 can reflect the level of immune function. |
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