| 李 钿,侯婷婷,赵万辉,王 英,索海燕.类风湿关节炎患者抗CCP，RF，AKA，ASO，RA33的临床价值分析[J].,2017,17(13):2456-2458 |
| 类风湿关节炎患者抗CCP，RF，AKA，ASO，RA33的临床价值分析 |
| Analysis of the Clinical Value of Anti - CCP, RF, AKA, ASO and RA33 in Patients with Rheumatoid Arthritis |
| 投稿时间：2016-11-06 修订日期：2016-11-25 |
| DOI：10.13241/j.cnki.pmb.2017.13.014 |
| 中文关键词: 类风湿关节炎 抗环瓜氨酸肽 类风湿因子 抗角蛋白抗体 抗链球菌溶血素"O" 抗RA33抗体 |
| 英文关键词: Rheumatoid arthritis Anti-cyclic citrullinated peptide Rheumatoid factor Anti-keratin antibody Anti-streptolysin "O" Anti-RA33 antibody |
| 基金项目:山东省自然科学基金重点资助项目(Z2010H564) |
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| 中文摘要: |
| 摘要 目的：分析抗抗环瓜氨酸肽(CCP)、类风湿因子（RF）、抗角蛋白抗体(AKA)、抗链球菌溶血素"O"（ASO、）抗RA33抗体对类风湿关节炎诊断的临床价值。方法：选取2015年3月至2016年2月本院收治的79例类风湿关节炎患者视为观察组，另选取同期本院收治的85例非类风湿关节炎自身免疫疾病者视为对照组。比较类风湿关节炎和非类风湿关节炎患者抗CCP、RF、AKA、ASO、RA33阳性情况，对抗CCP、RF、AKA、ASO、RA33的特异度和敏感度予以分析。结果：两组患者的ASO阳性率比较无显著性差异(P>0.05)，观察组的抗CCP、RF、AKA、RA33阳性率显著高于对照组(P<0.05)。抗CCP抗体诊断类风湿关节炎患者的敏感度为64.56%、特异度为92.94%；RF敏感度为60.46%、特异度为80.00%；AKA敏感度为51.90%、特异度为96.47%；ASO敏感度为10.13%、特异度为89.41%；抗RA33抗体敏感度为30.38%、特异度为95.29%。结论：抗CCP、RF、AKA、RA33对类风湿关节炎患者均具有较高的诊断价值，而ASO在类风湿关节炎患者中的诊断价值不明显。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinical value of anti-cyclic citrullinated peptide(CCP), rheumatoid factor(RF), anti-keratin antibodies(AKA), anti-streptolysin O (ASO), RA33 in diagnosis of rheumatoid arthritis. Methods: 79 patients with rheumatoid arthritis who were treated from March 2015 to February 2016 in our hospital were regarded as the observation group. 85 patients with autoim- mune diseases of rheumatoid arthritis who were admitted in our hospital in the same period were selected as the control group. The anti RFA, AKA, ASO and RA33 in patients with rheumatoid arthritis and non-rheumatoid arthritis were detected to analyze the specificity and sensitivity. Results: There was no significant difference in the ASO positive rate between the two groups. The positive rates of anti- CCP, RF, AKA, RA33 in the observation group were significantly higher than those in the control group (P<0.05). The sensitivity of anti- CCP for rheuma- toid arthritis patients was 64.56% and the specificity was 92.94%. The RF sensitivity was 60.46% and the specificity was 80.00%. The AKA sensitivity was 51.90% and the specificity was 96.47%. ASO sensitivity was 10.13% and specificity was 89.41%. The sensitivity of anti-RA33 antibody was 30.38% and the specificity was 95.29%. Conclusion: The anti-CCP, RF, AKA, RA33 had high diagnostic value for rheumatoid arthritis, while ASO was of little value in the diagnosis of rheumatoid arthritis. |
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