| 周 玎,傅美红,王嘉漫,韩兆勇,张 媛.思力华对慢性阻塞性肺疾病患者中性粒细胞、IL-8及TNF-α水平的影响[J].,2017,17(12):2306-2309 |
| 思力华对慢性阻塞性肺疾病患者中性粒细胞、IL-8及TNF-α水平的影响 |
| Clinical Effect of Seretide Combined with Spiriva on the Chronic Obstructive Pulmonary Disease Patients and Its Effect on Sputum Neutrophils, IL-8 and TNF-α Levels |
| 投稿时间：2016-11-12 修订日期：2016-11-30 |
| DOI：10.13241/j.cnki.pmb.2017.12.026 |
| 中文关键词: 舒利迭 思力华 慢性阻塞性肺疾病 中性粒细胞 白介素-8 肿瘤坏死因子-α |
| 英文关键词: Seretide Spiriva Chronic obstructive pulmonary disease Neutrophils IL-8 TNF-α |
| 基金项目:上海市科技发展项目(00JC14031)；上海市浦东新区卫生和计划生育委员会科研课题(201440060) |
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| 中文摘要: |
| 摘要 目的：探讨舒利迭联合思力华治疗慢性阻塞性肺疾病(COPD)患者的临床疗效及对患者痰液中性粒细胞、白介素(IL)-8、肿瘤坏死因子(TNF)-α水平的影响。方法：选取2015年8月~2016年7月来我院就诊的148例COPD缓解期患者，根据患者的入院顺序分成两组，每组74例。对照组治疗采取舒利迭，观察组联合给予思力华治疗，对比两组治疗效果、治疗前后肺功能、动脉血气分析相关指标以及痰中性粒细胞及IL-8、TNF-α水平的变化。结果：治疗后，观察组与对照组总有效率分别是94.59%、83.78%，观察组较对照组显著升高(P<0.05)。两组治疗后PaO2水平、6 min步行距离均较治疗前明显上升及增加，PaCO2水平明显下降(P<0.01)，且观察组血气分析指标显著优于对照组，6 min步行距离明显大于对照组(P<0.01)。两组治疗后FEV1、FEV1/FVC、FEV1%水平均较治疗前显著升高(P<0.01)，观察组各项肺功能指标改善效果显著优于对照组(P<0.01)。两组治疗后痰中性粒细胞计数与IL-8、TNF-α水平均较治疗前明显下降(P<0.01)，观察组痰中性粒细胞计数与IL-8、TNF-α水平明显低于对照组(P<0.05)。结论：舒利迭联合思力华治疗缓解期COPD可有效改善患者肺功能，缓解炎症反应，疗效确切。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of seretide combined with spiriva on chronic obstructive pulmonary disease (COPD) and its effect on the sputum neutrophils, interleukin (IL) -8 and tumor necrosis factor (TNF) -α levels. Methods: 148 cases of patients with COPD at remission stage treated in our hospital from August 2015 to July 2016 were selected and divided into two groups according to the patient's admission order, with 74 cases in each group. The control group was treated by seretide, while the observation group was combined with spiriva. Then the efficacy of both groups after treatment, the pulmonary function and arterial blood gas related indexes, sputum neutrophils and IL-8, TNF-α levels were compared between the two groups before and after treatment. Results: After treatment, the total effective rate of observation group and control group were 94.59% and 83.78% respectively, which was significantly higher in the observation group than that of the control group (P<0.05); after the treatment, the level of PaO2 and the walking distance within 6min were significantly increased while the level of PaCO2 was significantly decreased in both groups (P<0.01), the blood gas analysis index of observation group were significantly better than those of the control group, and the walking distance within 6min was significantly higher than that of the control group (P<0.01); after the treatment, the levels of FEV1, FEV1/FVC and FEV1% in both groups were significantly higher than those before the treatment (P<0.01), the improving effects of pulmonary function indexes in observation group were significantly better than those of the control group (P<0.01); after the treatment, the sputum neutrophil number and IL-8 and TNF-α levels in both groups were significantly decreased compared with those before the treatment (P<0.01), the sputum neutrophil nber and IL-8, TNF-α levels in the observation group were significantly lower than those in the control group (P<0.05). Conclusion: Seretide combined with spiriva could effectively improve pulmonary function, relieve the inflammation and had accurate curative effect on the patients with COPD at remission stage. |
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