| 姜 莹,王 暘,张卉蕾,纪春连,陈雪松.血管紧张素II 1型受体相关蛋白研究进展[J].,2017,17(11):2178-2180 |
| 血管紧张素II 1型受体相关蛋白研究进展 |
| Research Progress of Angiotensin II type 1 Receptor-associated Proteins |
| 投稿时间：2016-04-27 修订日期：2016-05-21 |
| DOI：10.13241/j.cnki.pmb.2017.11.047 |
| 中文关键词: 血管紧张素II 1型受体相关蛋白 血管紧张素受体相关蛋白1 GABAA受体相关蛋白 金属内肽酶3.4.24.15 GDP/GTP转换因子样蛋白 |
| 英文关键词: Angiotensin II type 1 receptor-associated protein(Atrap) Angiotensin receptor-associated protein 1(Arap1) GABAA re- ceptor-associated protein(GABARAP) Thimet oligopeptidase(EP24.15) GDP/GTP exchange factor (GEF)-like protein(GLP) |
| 基金项目:黑龙江省教育厅科学技术研究项目（12541435） |
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| 中文摘要: |
| 摘要：血管紧张素II（angiotensin II, AngII）作为肾素-血管紧张素系统（renin-angiotensin system, RAS）的关键效应因子，与血管紧张素II 1型受体（angiotensin II type 1 receptor, AT1R）结合后，在体内发挥维持体液及电解质平衡、收缩血管、调节血压，促进心肌、肾近端小管以及血管平滑肌细胞增殖，参与肿瘤的发生发展、血管形成和转移等重要作用。最新研究发现，AT1R相关蛋白特异性作用于AT1R蛋白的碳末端，通过调节受体的内化、细胞膜的再通和受体的敏感性对其表达进行控制，发挥相应的生物学作用。本文的重点在于对AT1R相关蛋白的研究进展进行综述，阐述不同AT1R相关蛋白在RAS系统中所起的作用，为RAS系统的进一步研究提供依据。 |
| 英文摘要: |
| ABSTRACT: Angiotensin II（Ang II）as the key effect factor of renin-angiotensin system（RAS）, binds with angiotensin II type 1 re- ceptor（AT1R）to maintain fluid and electrolyte balance, constrict blood vessels、regulate blood pressure, promote myocardium, renal proximal tubule and vascular smooth muscle cell proliferation, participate in the development、angiogenesis and metastasis of tumor, as well as other important roles. New studies have found that, AT1 receptor-associated protein binding with C-terminal region of AT1R spe- cially, control its expression by adjusting receptor internalization, cell membrane recycling and sensitivity of the receptor. This article briefly summarized the research progresses of several AT1R-associated proteins. Therefore it may provide new basis for further research of RAS in the furture. |
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