| 刘 慧,刘雄彪,汪晓红,庹 梅,陈亚会.清热散结片联合阿维A胶囊治疗难治性银屑病的疗效及对炎症反应的影响[J].,2017,17(11):2134-2136 |
| 清热散结片联合阿维A胶囊治疗难治性银屑病的疗效及对炎症反应的影响 |
| Efficacy of Heat Fights Piece combine with Avi A Capsule in The Treatment of Intractable Psoriasis and Its Influence on The Inflammatory Response |
| 投稿时间：2016-09-13 修订日期：2016-09-30 |
| DOI：10.13241/j.cnki.pmb.2017.11.035 |
| 中文关键词: 清热散结片 阿维A胶囊 难治性银屑病 疗效 |
| 英文关键词: Heat fights Enjoying A capsule Refractory psoriasis The curative effect |
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| 中文摘要: |
| 摘要 目的：分析清热散结片联合阿维A胶囊治疗难治性银屑病的疗效，并探讨其对炎症反应的影响。方法：选择2013年3月-2016年3月我院收治的100例难治性银屑病患者作为研究对象，按照随机数字表法分为对照组和观察组，每组各50例；对照组给予口服阿维A胶囊，观察组在对照组的基础上给予口服清热散结片；对比两组的临床疗效及不良反应发生情况，检测治疗前后血清肿瘤坏死因子（TNF-α）、白细胞介素-8（IL-8）及白细胞介素-4（IL-4）水平变化。结果：观察组的总有效率为96.00%（48/50），显著高于对照组的84.00%（42/50），差异有统计学意义（P<0.05）；治疗前两组TNF-α、IL-8及IL-4的水平对比，差异无统计学意义（P>0.05）,治疗后两组TNF-α、IL-8及IL-4水平均有所降低，且观察组显著低于对照组，差异有统计学意义（P<0.05）；治疗期间，两组无严重不良反应，差异无统计学意义（P>0.05）。结论：清热散结片联合阿维A胶囊治疗难治性银屑病的疗效显著，能够明显缓解患者机体的炎性反应，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: Efficacy of Heat Fights Piece combine with Avi A Capsule in The Treatment of Intractable Psoriasis and Its Influence on The Inflammatory Response, and to explore its effect on the inflammatory response. Methods: Selected 100 cases of patients with refractory psoriasis who were treated in our hospital from March 2013 to March 2016, and divided them into control group and ob- servation group according to random number table method 50 cases in each group; Control group given oral avi A capsule, on the basis of the control group ,the observation group were given oral heat fights combine with avi A capsule; Compared two groups of clinical curative effect and adverse reactions occur, changes of serum tumor necrosis factor (TNF-α), interleukin 8 (IL-8) and interleukin 4 (IL-4) level were tested before and after treatment. Results: Observation group total effective rate was 96.00% (48/50), significantly higher than that of control group 84.00% (42/50), the difference was statistically significant (P<0.05); The two groups before treatment TNF-α, IL-8 and the levels of IL-4 contrast, there was no statistically significant difference(P>0.05), the two groups after treatment TNF-α, IL-8 and IL-4 levels are reduced, and the observation group was significantly lower than the control group, the difference was statistically significant(P<0.05); During the treatment, no serious adverse reaction in both groups, there was no statistically significant difference(P>0.05). Conclusion: Combination of heat fights piece and avi A capsule in the treatment of refractory psoriasis can significantly alleviate inflammatory reaction of the patients body and improve the treatment effect, and it worthy of clinical application. |
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