| 赵甜甜,李洪春,彭 辉,徐 静,钮 威.AFU, AFP, GP73和GPC3联合检测对原发性肝癌的诊断价值[J].,2017,17(10):1941-1944 |
| AFU, AFP, GP73和GPC3联合检测对原发性肝癌的诊断价值 |
| Value of Combined Detection of AFU, AFP, GP73 and GPC3 in the Diagnosis of Primary Hepatic Carcinoma |
| 投稿时间：2016-07-13 修订日期：2016-07-31 |
| DOI：10.13241/j.cnki.pmb.2017.10.038 |
| 中文关键词: α-L-岩藻糖苷酶 甲种胎儿球蛋白 高尔基体蛋白73 磷脂酰肌醇蛋白聚糖3 原发性肝癌 |
| 英文关键词: AFU AFP GP73 GPC3 Primary hepatic carcinoma |
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| 中文摘要: |
| 摘要 目的：研究α-L-岩藻糖苷酶(AFU)、甲种胎儿球蛋白(AFP)、高尔基体蛋白73(GP73)和磷脂酰肌醇蛋白聚糖3(GPC3)联合检测对原发性肝癌的诊断价值。方法：选择2014年1月～2016年5月在我院进行诊治的原发性肝癌患者90例为肝癌组，同期住院诊治的肝硬化患者60例为肝硬化组，以及同期在我院体检健康者60例为对照组。比较三组的AFU、AFP、GP73和GPC3水平和阳性检出率，并观察AFU、AFP、GP73和GPC3单独检测和联合检测对原发性肝癌的诊断效率。结果：肝癌组和肝硬化组的AFU、AFP、GP73和GPC3水平均明显高于对照组（P<0.05），且肝癌组明显高于肝硬化组（P<0.05）；肝癌组和肝硬化组的AFU、AFP、GP73和GPC3阳性率均明显高于对照组（P<0.05），且肝癌组明显高于肝硬化组（P<0.05）；AFU、AFP、GP73和GPC3联合检测对原发性肝癌的特异性、敏感性、阳性预测值及阴性预测值均明显高于单独检测和三项指标联合检测 (P < 0.05)。结论：AFU、AFP、GP73和GPC3联合检测可以提高对原发性肝癌的检出率，具有较高的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To study the value of combined detection of α-L-fucosidase(AFU), alpha fetoprotein(AFP), Golgi protein 73 (GP73) and glypican 3 (GPC3) in the diagnosis of primary hepatic carcinoma. Methods: 90 cases of patients with primary hepatic carcinomawho were treated in our hospital from January 2014 to May 2015were selected as hepatic carcinoma group, 60 cases of patients with liver cirrhosis were selected as liver cirrhosis group, and 20 cases ofhealthy people were selected as control group. The level and positive rate of GPC3, AFP, GP73 and AFU was compared between the three groups, and the diagnostic efficiency of AFU, AFP, GP73 and GPC3 for primary hepatic carcinoma were observed. Results: TheAFU, AFP, GP73 and GPC3 level of hepatic carcinoma group and liver cirrhosis group was significantly higher than that of control group (P<0.05), and it was significantly higher in hepatic carcinoma group than that of liver cirrhosis group (P<0.05); the positive rate of AFU, AFP, GP73 and GPC3 of hepatic carcinoma group and liver cirrhosis group was significantly higher than that of control group (P<0.05), and it was significantly higher in hepatic carcinoma group than that of liver cirrhosis group (P<0.05); the specificity, sensitivity, positive predictive value and negative predictive value of AFU, AFP, GP73 and GPC3 combined detection were significantly higher than that of single detection and combined detection (P<0.05). Conclusion: The combined detection of AFU, AFP, GP73 and GPC3 can improve the detection rate of primary hepatic carcinoma, and has high clinical application value. |
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