| 丁 玎,宋 怡,黄凤敏,夏桂香.中西医结合治疗对肠梗阻患者免疫功能与炎症反应的影响[J].,2017,17(10):1874-1878 |
| 中西医结合治疗对肠梗阻患者免疫功能与炎症反应的影响 |
| Effect of Integrated Therapy of Traditional Chinese and Western Medicine on Immune Function and Inflammatory Reaction of Patients with Intestinal Obstruction |
| 投稿时间：2016-09-30 修订日期：2016-10-21 |
| DOI：10.13241/j.cnki.pmb.2017.10.019 |
| 中文关键词: 肠梗阻 柴芩承气汤 免疫 炎症反应 |
| 英文关键词: Intestinal obstruction Chaiqin Chengqi Decoction Immunity Inflammation |
| 基金项目:四川省科技厅科技支撑项目(0040205318D68) |
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| 中文摘要: |
| 摘要 目的：探讨柴芩承气汤加减联合西医治疗对肠梗阻（IO）患者临床疗效、免疫功能及急性炎症反应的影响。方法：将486例肠梗阻患者随机分配为西医治疗组（对照组，n=243）与中西医结合治疗组（治疗组，n=243），对照组患者进行西医常规治疗，治疗组在对照组治疗基础上应用柴芩承气汤加减治疗。治疗前后检测并比较两组患者血清前蛋白（PA）、白蛋白（Alb）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）、白细胞计数（WBC）、C反应蛋白（CRP）变化，比较患者T淋巴细胞亚群的比例、血浆二胺氧化酶（DAO）、乳果糖/甘露醇比值（L/M）变化。结果：治疗组临床疗效与临床症状改善显著高于对照组（P＜0.05）；治疗组治疗后PA、Alb指标显著提高（P＜0.05），IL-6、IL-8、TNF-α、WBC、CRP指标显著降低（P＜0.05）；治疗组血浆DAO与L/M指标显著降低（P＜0.05）；与本组治疗前比较，治疗组患者血清CD4+、CD8+、CD4+/ CD8+与IgA、IgG指标显著提高（P＜0.05）；与对照组同期比较，治疗组血清CD4+、CD8+、CD4+/ CD8+与IgA指标显著提高，差异有统计学意义（P＜0.05）。结论：柴芩承气汤加减联合西医治疗肠梗阻可以显著减轻患者炎症反应，改善免疫功能，修复胃肠道黏膜，疗效显著。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Chaiqin Chengqi decoction combined with Western medicine treatment on the immune function, clinical efficacy and acute inflammatory reaction of intestinal obstruction (IO) patients. Methods: 486 IO patients were randomly assigned into the Western medicine treatment group (control group, n=243) and Traditional Chinese medicine (TCM) combined with Western medicine treatment group (treatment group, n=243). The control group was treated with conventional western medicine treatment, while the treatment group was treatment with Chaiqin Chengqi decoction on the basis of control group. Then we detected and compared the serum protein (PA), albumin (Alb), interleukin -6 (IL-6), interleukin -8 (IL-8), tumor necrosis factor alpha (TNF- alpha), white blood cell count (WBC), C reactive protein (CRP) changes of patients in two groups before and after treatment. We also compared the proportion of T lymphocyte subsets, plasma diamine oxidase (DAO) and lactulose / mannitol ratio (L/M) changes. Results: The clinical efficacy and the improvement of clinical symptoms in the treatment group was significantly better than in the control group (P<0.05). PA, Alb of treatment group increased significantly (P<0.05), yet the levels of IL-6, IL-8, TNF-α, WBC and CRP decreased significantly (P<0.05). DAO and L/M were significantly decreased in the treatment group (P<0.05). Compared with before treatment, serum CD4+, CD8+, CD4+/CD8+, IgG and IgA of treatment group significantly increased after treatment(P<0.05). Compared with the control group, serum CD4+, CD8+, CD4+/ CD8+ and IgA of the treatment group increased significantly, and the difference was statistically significant (P<0.05). Conclusion: Chaiqin Chengqi decoction combined with Western medicine can significantly reduce inflammation, improve immune function, and repair the gastrointestinal mucosa in the treatment of patients with intestinal obstruction. It showed remarkable curative effects. |
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