| 韦 华,蒙连新,耿 琳,郭星荣,李美江,罗桂情,黄秀芳.2型糖尿病患者微血管病变与血清代谢学指标的关系[J].,2017,17(9):1713-1715 |
| 2型糖尿病患者微血管病变与血清代谢学指标的关系 |
| Relationship between Microvascular Lesions and Serum Metabolic Parameters in Patients with Type 2 Diabetes Mellitus |
| 投稿时间：2016-12-02 修订日期：2016-12-24 |
| DOI：10.13241/j.cnki.pmb.2017.09.030 |
| 中文关键词: 2型糖尿病 微血管病变 Hcy CysC VEGF |
| 英文关键词: Type 2 diabetes mellitus Microvascular lesions Hcy CysC VEGF |
| 基金项目:百色市科学研究与技术开发计划项目（2014jjAA40430） |
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| 中文摘要: |
| 摘要 目的：探讨2型糖尿病（T2DM）患者微血管病变与血清代谢学指标的关系。方法：选择我院于2015年7月~2016年7月间收治的T2DM患者共96例，按是否存在微血管病变分为观察组（n=43，存在微血管病变）及对照组（n=53，无微血管病变）。检测并对比两组患者血清中三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、空腹血糖（FBG）、糖化血红蛋白（HbA1C）、同型半胱氨酸（Hcy）、血清胱抑素C（CysC）及血管内皮生长因子（VEGF）水平，并采用 logistic 回归分析T2DM微血管病变的危险因素。结果：观察组病程、吸烟率高于对照组，差异有统计学意义（P<0.05）；观察组TG、LDL、HbA1C、CysC、Hcy、VEGF水平均高于对照组，差异均有统计学意义（P<0.05）；两组TC、HDL水平比较，差异无统计学意义（P>0.05）；经logistic 回归分析显示，病程、CysC、Hcy、VEGF为微血管病变的危险因素（OR=1.975，3.643，4.054，4.214，P<0.05）。结论：CysC、Hcy、VEGF为微血管病变的危险因素，对其水平的检测有助于早期T2DM微血管病变诊断及治疗。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between microvascular lesions and serum metabolic parameters in patients with type 2 diabetes mellitus(T2DM). Methods: Selected 96 patients with T2DM in our hospital from July 2015 to July 2016, According to the presence of microvascular lesions were divided into observation group(n=43, with microvascular lesions)and control group(n=53,without microvascular lesions). Detected the levels of triacylglycerol(TG), total cholesterol(TC), high density lipoprotein(HDL), low den- sity lipoprotein (LDL), fasting blood glucose(FBG), glycosylated hemoglobin(HbA1C), homocysteine(Hcy)and serum cystatin C(CysC)and vascular endothelial growth factor(VEGF). Logistic regression analysis was used to analyze the risk factors of microvascular lesions. Results: Course of disease, smoking rate in observation group was higher than the control group, the difference was statistically signifi- cant(P<0.05); The levels of TG, LDL, HbA1C, CysC, Hcy, VEGF were higher than the control group, the differences were statistically significant(P<0.05), but the TC and HDL levels in two groups had no significant difference(P>0.05); Logistic regression analysis showed that the course of disease, CysC, Hcy, VEGF were the risk factors for microvascular lesions(OR=1.975, 3.643, 4.054, 4.214, P<0.05). Conclusion: CysC, Hcy, VEGF are the risk factors of the microvascular lesions, detecting these indexes is helpful to diagnosis and treat- ment of early T2DM with microvascular lesions. |
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