| 蒋 利,丁 盛,张立平,李运明,江忠勇,彭 燕,张近宝.血浆中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的变化与婴幼儿先心病术后急性肺损伤的关系[J].,2017,17(8):1570-1573 |
| 血浆中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的变化与婴幼儿先心病术后急性肺损伤的关系 |
| The Correlation between Plasma Neutrophil Gelatinase-associated Lipocalin(NGAL) and Acute Lung Injury in Infants and Young Children after Congenital Heart Disease |
| 投稿时间：2016-05-20 修订日期：2016-06-12 |
| DOI：10.13241/j.cnki.pmb.2017.08.044 |
| 中文关键词: 中性粒细胞明胶酶相关脂质运载蛋白 肺损伤、婴幼儿 |
| 英文关键词: Neutrophil gelatinase-associated lipocalin Lung injury Infant |
| 基金项目:成都军区总医院立项课题（417311C5） |
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| 中文摘要: |
| 摘要 目的：明确血浆中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的变化能否预测婴幼儿先心病术后急性肺损伤(ALI)的发生。方法：纳入2013年10月至2014年5月年龄≤36月的先心病合并肺动脉高压的婴幼儿患者的相关资料，检测体外循环(CPB)术后2 h、12 h、24 h、48 h和72 h的血浆NGAL水平，分析NGAL与术后发生ALI之间的关系。结果：本研究共纳入患者61例，术后发生ALI患者9例(14.8 %)。所有患者CPB术后5个时间点的变化趋势为：CPB术后2 h NGAL浓度开始升高，均值为27.28 μg/L，至12 h达到最高峰，均值为30.61 μg/L，24 h开始下降；其中12 h、24 h和72 h与前一时间点比较均具有显著性差异(P<0.05)。进一步分组显示，NGAL浓度变化趋势主要在ALI组：ALI组患者12 h、24 h、48 h和72 h的NGAL浓度与前一个时间点比较，变化均具有显著差异(P<0.05)，NGAL峰值浓度出现在12 h，其均值为40.82 μg/L；而无ALI组患者NGAL浓度只在24 h和12 h之间比较有显著差异(P<0.05)；ALI组患者5个时间点的NGAL浓度均比无ALI组患者高，具有显著性差异(P<0.05)。结论：血浆NGAL在早期预测婴幼儿体外循环术后发生ALI可能具有重要作用。 |
| 英文摘要: |
| ABSTRACT Objective: To test whether plasma neutrophil gelatinase-associated lipocalin (NGAL) can predict acute lung injury (ALI) in infants and young children after cardiac surgery. Methods: Children who were ≤36 months of age and had congenital heart disease with pulmonary hypertension between October 2013 and May 2014 were included. We detected the plasma concentration of NGAL at 2 h, 12 h, 24 h, 48 h and 72 h after cardiopulmonary bypass(CPB) to understand the correlation between NGAL and ALI. Results: Nine of 61 patients (14.8 %) developed ALI after CPB. Concentrations of NGAL in all patients rose from a mean of 27.28 μg/L 2 h after CPB, reached the peak level of 30.61 μg/L at 12 h after CPB and then decreased at the following 3 timepoints. This variation trend of concentrations of NGAL was mainly found in group ALI, compared with the previous timepoints, the concentrations of NGAL at 12 h, 24 h, 48 h and 72 h were significantly differences respectively (P<0.05), the peak level was 40.82 μg/L 12 h after CPB. Whereas significant difference was only found between 12 h and 24 h in group without ALI. Concentrations of NGAL were significant higher in group ALI than in group without ALI at all 5 timepoints. Conclusion: Plasma NGAL may play a role in early prediction of ALI in infants and young children after cardiac surgery. |
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