| 杨丽娟,许美善,曹丽芳,闫宗荣,孙金苹.小儿难治性支原体肺炎血清TNF-α、IL-4、IL-10水平变化及临床意义[J].,2017,17(8):1487-1489 |
| 小儿难治性支原体肺炎血清TNF-α、IL-4、IL-10水平变化及临床意义 |
| The Serum Level Changes of TNF-α, IL-4 and IL-10 in Children with Refractory Mycoplasma Pneumoniae Pneumonia and Its Clinical Significance |
| 投稿时间：2016-07-15 修订日期：2016-08-10 |
| DOI：10.13241/j.cnki.pmb.2017.08.021 |
| 中文关键词: 小儿 难治性支原体肺炎 TNF-α IL-4 IL-10 水平 临床意义 |
| 英文关键词: Children Refractory mycoplasma pneumoniae pneumonia TNF-α IL-4 IL-10 Level Clinical significance |
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| 中文摘要: |
| 摘要 目的：探讨小儿难治性支原体肺炎(RMPP)血清肿瘤坏死因子-α（TNF-α）、白细胞介素-4（IL-4）、白细胞介素-10（IL-10）水平变化及临床意义。方法：选自我院2013年1月至2016年1月收治的90例RMPP住院患儿设为RMPP组，根据肺炎严重指数（PSI）评分标准分为重症肺炎组（30例）和非重症肺炎组（60例），并选择同期健康体检的健康儿童为50例对照组。并对患儿进行跟踪、随访，收集47例患儿作为RMPP恢复期组，采用酶联免疫吸附法（ELISA）检测各组血清中TNF-α、IL-4、IL-10的水平变化。结果：RMPP组、RMPP恢复期组患者血清中TNF-α、IL-4和IL-10水平明显高于对照组（P＜0.05）；RMPP组患者血清中以上三个指标均明显高于RMPP恢复期组（P＜0.05）；重症肺炎组有纤维化改变和无纤维化的患儿血清中TNF-α、IL-4和IL-10水平均高于非重症肺炎组患儿血清（P＜0.05）；重症肺炎组和非重症肺炎组内出现纤维化改变的患儿血清中TNF-α、IL-4和IL-10水平均高于无纤维化患儿（P＜0.05）；PSI评分与TNF-α、IL-4和IL-10的水平呈正相关（P＜0.05）。结论：TNF-α、IL-4和IL-10水平参与了RMPP的发病过程，它们高水平表达与病情严重程度密切相关，可以作为早期诊断RMPP及控制病情发展的重要依据。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the serum level changes of tumor necrosis factor-α (TNF-α), interleukin-4(IL-4) and interleukin-10(IL-10) in children with refractory mycoplasma pneumoniae pneumonia and its clinical significance. Methods: A total of 90 cases with RMPP who were admitted in our hospital were include in the study and served as the RMPP group. According to the pneumonia severity index(PSI) is divided into the severe pneumonia group (30 cases) and non severe pneumonia group (60 cases), and selected 50 cases of healthy children as the control group. The children with RMPP were followed up and 47 cases were collected as the RMPP recovery group. The serum level changes of TNF-α, IL-4 and IL-10 in each group were measured by enzyme-link immunosorbent assay (ELASA). Results: The serum level of TNF-α, IL-4 and IL-10 levels in the RMPP group, recovery RMPP group were significantly higher than the control group (P＜0.05); The serum level of the above three indicators in the RMPP group with were significantly higher than recovery RMPP group (P＜0.05); The serum level of TNF-α,IL-4 and IL-10 levels in the severe pneumonia group with fibrosis and no fibrosis were higher than non-severe pneumonia group (P＜0.05); The serum level of TNF-α, IL-4 and IL-10 levels with fibrosis were higher than those with non-fibrosis in the severe pneumonia group and non-severe pneumonia group (P＜0.05); The TNF-α, IL-4, IL-10 and PSI score are positively related (P＜0.05). Conclusion: The TNF-α, IL-4 and IL-10 were involved in the pathogenesis of RMPP, and their high level were closely related with the severity degree; They could provide an important evidence for the early clinical diagnosis and controlling the development of the disease. |
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