| 周萍 王聪 王晓琴 杨玉琮 赵车东.乙肝患者血清标志物与肝纤维化血清学指标的相关性分析[J].,2017,17(7):1350-1352 |
| 乙肝患者血清标志物与肝纤维化血清学指标的相关性分析 |
| Correlative Analysis of the Hepatitis B Serological Biomarkers with SerumLiver Fibrosis Biomarkers |
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| DOI： |
| 中文关键词: 乙肝 肝纤维化 乙肝病毒核酸含量 |
| 英文关键词: Hepatitis B Liver fibrosis Hepatitis B virus nucleic acid content |
| 基金项目:陕西省科技计划项目（2013K12-05-12） |
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| 中文摘要: |
| 目的：探讨乙肝患者血清标志物与肝纤维化血清学指标的相关性。方法：收集我院收治的136 例乙型病毒肝炎患者，根据轻
中重程度分为轻度组、中度组以及重度组，每组42 例。观察并比较所有患者乙肝血清标志物、HBV-DNA水平、透明质酸(HA)，血
清Ⅲ型前胶原肽(PCIII)，Ⅳ型胶原(CIV)水平以及层粘连蛋白(LN)水平。结果：三组患者的HBV-DNA水平依次升高，与轻度组相
比，中度组、重度组患者HBV-DNA水平较高，与中度组患者相比，重度组患者HBV-DNA 水平较高，差异具有统计学意义(P<0.
05)。与轻度组相比，中度组、重度组患者HA、PCIII、CIV、LN 水平较高，与中度组患者相比，重度组患者HA、PCIII水平较高，差异
具有统计学意义(P<0.05)；HBV-DNA 水平与HA、PCIII、CIV、LN 水平均呈显著正相关。结论：乙肝患者的血清学检测指标与血清
肝纤维化测定有助于对乙肝的纤维化过程的进展情况进行评估。 |
| 英文摘要: |
| Objective:To investigate the significance of serumliver fibrosis in patients with hepatitisBin clinical research.Methods:136 cases of hepatitis B patients admitted to our hospital were divided into 3 groups according to the degree of mild, moderate, severe,
mild group, moderate group and severe group, 42 cases in each group. All patients were observed and compared with HBV markers,
HBV-DNA levels, hyaluronic acid (HA), serumtype III collagen peptide (PCIII), type IV collagen (CIV) and laminin (LN) levels.Results:HBV-DNA levels in three groups of patients was gradually increased, compared with that of the mild group, moderate group and severe
group and the HBV-DNA level are higher, and compared with moderate group patients, severe group patients HBV-DNA level is higher,
the difference is statistically significant (P<0.05). Compared with the mild group, moderate group and severe group patients HA, PCIII,
civ and LN levels are higher, and compared with moderate group patients, patients in the severe group ha, PCIII level is higher, the difference
is statistically significant (P<0.05); HBV-DNA level was positively correlated with the HA, PCIII, CIV and LN levels.Conclusion:The serological detection indexes of hepatitis B patients and serum liver fibrosis were determined, which could be used to evaluate the
progress of hepatitis B fibrosis process. |
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