| 王岩松 刘建林 王梓仪 张晓东 陈曦.关节灌洗术联合透明质酸钠注射治疗颞下颌关节骨关节炎的疗效观察[J].,2017,17(7):1304-1307 |
| 关节灌洗术联合透明质酸钠注射治疗颞下颌关节骨关节炎的疗效观察 |
| Effect of SodiumHyaluronate Injection and Arthrocentesis for Patients withTemporomandibular Joint Osteoarthritis |
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| DOI： |
| 中文关键词: 颞下颌关节骨关节炎 关节灌洗术 透明质酸钠 炎症 |
| 英文关键词: Temporomandibular joint osteoarthritis Arthrocentesis Sodiumhyaluronate Inflammation |
| 基金项目:深圳市科技研发基金项目（JCYJ20120827172450676） |
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| 中文摘要: |
| 目的：评价关节腔灌洗联合透明质酸钠注射治疗颞下颌关节骨关节炎（TMJOA）的疗效及安全性。方法：选取我院2014 年5
月-2015 年5月收治颞下颌关节骨关节炎患者68 例作为研究对象，根据入院时间先后顺序按照随机数字表法随机分为实验组和
对照组各34 例。所有患者在颞颌关节区域局麻下建立关节上腔的双通道灌洗系统，实验组用生理盐水反复冲洗关节腔后注射透
明质酸钠，对照组只进行关节腔灌洗术，术后随访对比两组治疗前、治疗后4 周、6 个月时患者非辅助最大开口度、侧向运动幅度、
咀嚼时疼痛感；同时采用酶联免疫吸附法（ELISA）测定两组治疗前、治疗后4 周血清中白细胞介素6（IL-6）和肿瘤坏死因子alpha
（TNF-alpha）水平并进行比较。结果：实验组患者治疗后4 周、治疗后6 个月时颞下颌关节最大张口度和侧向活动距离明显增大，而咀
嚼时疼痛感明显减轻，且优于同期对照组，差异具有统计学意义（P＜0.05)；实验组患者治疗后4 周时血清IL-6、TNF-alpha水平较术
前及同时期对照组均明显降低，差异具有统计学意义（P＜0.05）。结论：关节灌洗术联合透明质酸钠注射是治疗颞下颌关节骨关节
炎的简单、安全有效治疗方法，治疗效果明显优于单纯关节腔灌洗，值得临床推广应用。 |
| 英文摘要: |
| Objective:To evaluate the effect of sodiumhyaluronate injection and arthrocentesis for patients with temporomandibular
joint osteoarthritis.Methods:68 patients hospitalized with temporomandibular joint osteoarthritis from May 2014 to May 2015 were
selected, and randomly divided into two groups with 34 cases in each. Observation group recieved underwent joint lavage combined with
intra-articular injection of sodium hyaluronate by dual-channel irrigation system, but the patients only with joint lavage in control group.
Compared the non-assisted maximum opening degree of mouth, degree of lateral movement and values of pain during chewing were
measured at the baseline of two groups before treatment, 4 weeks and 6 months after treatment. The seruminterleukin-6 (IL-6) and tumor
necrosis factor-alpha(TNF-alpha) levels of two groups were determined by enzyme-linked immunosorbent assay (ELISA) before treatment,4
weeks and 6 months after treatmen.Results:In observation group, the non-assisted maximum opening degree of mouth, degree of lateral
movement were significantly increased and the value of pain was significantly reduced 4 weeks and 6 months after treatmen, and better
than the same period of the control group, the difference was statistically significant (P<0.05). Compared with the preoperative and control
group, postoperative levels of serumIL-6, TNF-alpha in observation group were reduced with significantly difference (P<0.05).Conclusion:Arthrocentesis combined with intra-articular injection of sodiumhyaluronate is a simple, effective means for temporomandibular joint osteoarthritis.
Its therapeutic effect is superior to the simple joint cavity lavage, which is worthy of clinical application. |
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