| 刘瑞 刘光金 刘艳芬 冯四平 任竞.沙格列汀联合二甲双胍对2型糖尿病的疗效与安全性分析[J].,2017,17(6):1113-1116 |
| 沙格列汀联合二甲双胍对2型糖尿病的疗效与安全性分析 |
| Efficacy and Safety of Saxagliptin Combined with Metformin in theTreatment of 2 Type Diabetes |
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| DOI： |
| 中文关键词: 二甲双胍 沙格列汀 阿卡波糖 2 型糖尿病 疗效 |
| 英文关键词: Metformin Aaxagliptin Acarbose 2 type diabetes Efficacy |
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| 中文摘要: |
| 目的：探讨沙格列汀联合二甲双胍对2 型糖尿病的疗效与安全性。方法：选取200 例2 型糖尿病患者，按随机数字表法分为
两组，沙格列汀组(102 例)口服沙格列汀联合二甲双胍治疗，阿卡波糖组(98 例)口服阿卡波糖联合二甲双胍治疗。通过观察并记录
治疗前后糖代谢情况与体重指数水平，SF-36 量表各项评分，治疗期间不良反应情况，评价沙格列汀联合二甲双胍对2 型糖尿病
的疗效与安全性。结果：治疗后，两组HbA1c，BMI，FBG，2 hPBG水平均明显下降(P<0.05)，且沙格列汀组患者HbA1c，BMI，FBG，
2 hPBG 水平明显低于阿卡波糖组(P<0.05)；治疗后3 个月两组患者SF-36 表各项评分均明显提高(P<0.05)，但两组间差异没有统
计学意义(P>0.05)；随访期间，两组不良反应率相比，差异没有统计学意义(P>0.05)。结论：沙格列汀联合二甲双胍可以明显控制患
者血糖水平，减轻患者体重，提高患者生活质量，用药安全性好，值得临床推广使用。 |
| 英文摘要: |
| Objective:To investigate the efficacy and safety of saxagliptin combined with metformin in the treatment of 2 type
diabetes.Methods:200 patients who had 2 type diabetes were selected and divided into two groups randomly. The patients in saxagliptin
group (102 cases) were given saxagliptin combined with metformin, and the patients in acarbose group (98 cases) were given saxagliptin
combined with metformin. The efficacy and safety of saxagliptin combined with metformin in the treatment of 2 type diabetes was
evaluated by the detection of the indexes of glucose metabolism and body weight, SF-36 scores before and after treatment and adverse
reactions during therapy.Results:After treatment, the HbA1c, BMI, FBG, 2hPBG level of two group were decreased (P<0.05), and the
HbA1c, BMI, FBG, 2hPBG level of the saxagliptin group were lower than that of the acarbose group (P<0.05). After treatment, the SF-36
scores of two groups were increased (P<0.05), but there were no statistical significance on SF-36 scores between two groups (P>0.05).
During treatment, there were no statistical significance on the incidence of adverse reactions between two groups (P>0.05).Conclusion:Saxagliptin combined with metformin can significantly control the blood glucose levels and improve the quality of life of patients with
good safety, worthy of clinical application. |
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