| 李玲 马燕玲 马华玲 张文娟 郑明军.E-cadherin 在宫颈上皮内瘤变及宫颈癌中的表达及其与高危型HPV感染的相关性[J].,2017,17(6):1090-1093 |
| E-cadherin 在宫颈上皮内瘤变及宫颈癌中的表达及其与高危型HPV感染的相关性 |
| Expression of E-cadherin in Cervical Cancer and Cervical intraepithelialNeoplasia and Its Correlation with High Risk HPV Infection |
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| DOI： |
| 中文关键词: 宫颈上皮内瘤变 宫颈癌 E-cadherin 高危型人乳头瘤病毒 PCR-反向点杂交法 |
| 英文关键词: Cervical intraepithelial neoplasia Cervical cancer E-cadherin High risk human papillomavirus PCR- reverse dot blot
hybridization method |
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| 中文摘要: |
| 目的：研究各级宫颈上皮内瘤变(CIN) 及宫颈癌组织中E-cadherin 的表达及其与高危型人乳头瘤病毒(high risk human
papillomavirus，HR-HPV)感染的相关性，探讨其在宫颈疾病发生、发展中的意义。方法：选取2008 年1 月至2014 年12月我院收
治的150 例患者标本，并将其分为CINⅠ级组、CINⅡ-Ⅲ级组及宫颈癌组，用免疫组化法对E-cadherin 的表达情况进行检测，并于
术前采用PCR-反向点杂交法检测患者高危型HPV 感染情况，所得结果进行统计学分析。结果：(1)E-cadherin 在CINⅠ级、CINⅡ
-Ⅲ级及宫颈癌中的阳性表达率分别为40/50(80.0 %)、24/50(48.0 %)、17/50(34.0 %)，随疾病的进展E-cadherin 的表达明显减少，各
组间差异有统计学意义(P<0.05)。(2)高危型HPV在CINI 级、CINⅡ-Ⅲ级及宫颈癌中的阳性感染率分别为21/50(42.0 %)、38/50
(76.0 %)、48/50(96.0 %)，各组间差异有统计学意义(P<0.05)。(3)在CIN 和宫颈癌中，HR-HPV 阳性组中E-cadherin 阳性率39.3 %
(42/107)低于HR-HPV 阴性组中E-cadherin 阳性率90.7 %(39/43)(P<0.05)。结论：E-cadherin 的表达下降或缺失可能是HR-HPV 导
致宫颈癌发生、发展的机制之一。 |
| 英文摘要: |
| Objective:To study the expession of E-cadherin, high risk human papillomavirus (HR-HPV) in cervical cancer and
pre-malignant lesion, and discuss the role of them in occurrence and development of cervical cancer.Methods:From January 2008 to
December 2014, 150 cases of cervical cance and pre-malignant lesion were collected. Cervical tissues were divided into CIN grade I
group, CIN grade II -III group and cervical cancer group. The expressions of E-cadherin were detected by immunohistochemical method,
the high-risk HPV infection in the patients were detected by PCR-reverse dot blot hybridization method, and the statistical analysis was
performed.Results:(1) The positive expression of E-cadherin in groups were respectively 80.0 %, 48.0 %, 34.0 %. There were significant
differences in CIN grade I, CIN II-III and cervical cancer groups (P<0.05); The expression of E-cadherin was significantly decreased with
the progression of disease, and there were significant differences between the groups (P<0.05). (2) Positive infection rate of HR-HPV in
CIN grade I, CIN II-III and cervical cancer groups were 42.0 %, 76.0 %, 96.0 %. There were significant differences between the groups
(P<0.05). (3) In CIN and cervical cancer, the positive rate of E-cadherin in HR-HPV positive group was 39.3% (42/107) lower than that
in HR-HPV negative group was 90.7%(39/43) (P<0.05); In CIN and cervical cancer, The expression of E-cadherin was negatively
correlated with high risk type HPV infection.Conclusion:The decrease or loss of E-cadherin expression may be one of the mechanisms
of HR-HPV in the genesis and development of cervical cancer. |
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